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公开(公告)号：EP0966528A1
公开(公告)日：1999-12-29
申请号：EP98960164.0
申请日：1998-11-06
发明人： BOSTIAN, Keith , NATSOULIS, Georges
CPC分类号： C12N15/1079 , C12Q1/025 , C12Q1/6897
摘要： A two-step, scalable method is described for identifying the cellular function(s) of one or more genes of unknown function, and for identifying modulators or the gene(s). The method uses the reversal or alteration of a phenotype created by the expression of the heterologous gene, e.g., a human gene, to identify modulators of that gene's activity. That modulator is then used in an in vitro or in vivo disease model system to identify compounds which affect disease progression. The subset of compounds which influence disease in a therapeutic manner are drug leads. However, all compounds which influence disease progression are tools to at least partially characterize gene function. The inhibitor identification step or the method is preferably carried out using a plurality of microbial strains or cell lines expressing different heterologous DNA sequences in a single solution. The method is particularly useful for genes which have not been validated as good inhibitor targets.
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2.发明公开
公开(公告)号：EP1328880A1
公开(公告)日：2003-07-23
申请号：EP01981547.1
申请日：2001-10-11
CPC分类号： G06F19/28 , C12Q2600/158 , G06F19/20 , Y10S707/99943
摘要： An interactive system for facilitating hypothesis construction by correlating and presenting gene expression data, bioassay data, and compound activity data, and associating gene and compound function information with product information, and facilitating product purchase. The user uploads data into the system (200) or browses (205) for a gene, compound or profile of interest already present in the system (200). Data is displayed along with hyperlinks (230) to related information, allowing the user to flag any selected product (240).
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