公开(公告)号：EP4397758A1

公开(公告)日：2024-07-10

申请号：EP22858494.2

申请日：2022-08-17

Applicant: Public University Corporation Yokohama City University

Inventor： ADACHI, Noritaka

IPC: C12N15/11 ,  A61K48/00 ,  A61P35/00 ,  C12N15/63 ,  C12Q1/6897 ,  G01N33/15 ,  G01N33/50

CPC classification number: A61K48/00 ,  A61P35/00 ,  C12N15/11 ,  C12N15/63 ,  C12Q1/6897 ,  G01N33/15 ,  G01N33/50

Abstract: Disclosed are a means which enables simple and rapid detection of the presence or absence, and of the degree, of HR activity in an individual, and a means which is useful for detection and treatment of homologous recombination-restored cancer for which no treatment means is available at present. The nucleic acid construct of the present invention is a nucleic acid construct comprising a set of a first nucleic acid molecule and a second nucleic acid molecule, the first nucleic acid molecule comprising: a promoter region; and a mutant gene sequence operably linked downstream thereof, the mutant gene sequence being constituted by a gene sequence encoding a protein and a cleavage site arranged inside thereof; the second nucleic acid molecule comprising a complementation region capable of replacing, by homologous recombination, a partial region comprising the cleavage site in the mutant gene sequence, the complementation region being constituted by a first homologous region and a second homologous region. The construct is useful as a measurement reagent or kit for homologous recombination activity, a diagnostic agent for homologous recombination-deficient cancer, a therapeutic agent for homologous recombination-restored cancer, or the like.

公开(公告)号：EP4366767A2

公开(公告)日：2024-05-15

申请号：EP22838408.7

申请日：2022-07-07

Applicant: Temple University - Of The Commonwealth System of Higher Education

Inventor： HU, Wenhui

IPC: A61K39/215 ,  C07H21/02

CPC classification number: C07K2319/3520130101 ,  C12P21/02 ,  C12Q1/6897 ,  C12N2770/2002220130101 ,  C12N2830/1520130101 ,  C12N2740/1604320130101 ,  C07K14/005 ,  C12N15/86 ,  C12N2770/2003420130101 ,  A61K39/12 ,  A61K2039/5320130101 ,  C07K2317/1420130101 ,  C07K16/1003

公开(公告)号：EP3380195A1

公开(公告)日：2018-10-03

申请号：EP17736473.4

申请日：2017-01-06

Applicant: Institute for Systems Biology

Inventor： PETERSON, Eliza ,  BALIGA, Nitin S.

IPC: A61P31/00 ,  A61P31/04 ,  A61P31/06 ,  A61K31/50 ,  A61K31/713 ,  A61K45/00 ,  C12N15/09

CPC classification number: C12Q1/689 ,  C12Q1/6897 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N2333/4703 ,  G01N2800/12

Abstract: Practical assays to identify compounds that overcome the resistance of M. tuberculosis to bedaquiline are based on transcription factors Rv0324 and Rv0880 shown to mediate this resistance.

公开(公告)号：EP2489674B1

公开(公告)日：2018-07-11

申请号：EP12163003.2

申请日：2009-03-04

Applicant: Agenus Inc.

Inventor： Grawunder, Ulf ,  Stitz, Jörn

IPC: C07K16/00 ,  C12N15/867 ,  C07K14/435 ,  G01N33/569 ,  C07K14/705

CPC classification number: G01N33/6854 ,  C07K14/43595 ,  C07K16/00 ,  C07K16/18 ,  C07K2317/21 ,  C12N5/0635 ,  C12N9/78 ,  C12N15/1037 ,  C12Q1/6897 ,  C40B30/04 ,  G01N33/56966 ,  G01N33/56972

Abstract: The present invention discloses novel methods for the generation, expression and screening of diverse collections of binding proteins such as antibodies or fragments thereof in vertebrate host cells in vitro, for the identification and isolation of ligand- or antigen-specific binding proteins. The methods disclosed herein allow the expression of diverse collections of binding proteins from at least one vector construct, which optionally can give rise to collections of diverse binding proteins upon transfer and expression into vertebrate host cells in situ .

公开(公告)号：EP3169776A4

公开(公告)日：2018-07-04

申请号：EP15822737

申请日：2015-07-14

Applicant: UNIV CALIFORNIA

Inventor： GILBERT LUKE A ,  HORLBECK MAX ,  KAMPMANN MARTIN ,  QI LEI S ,  WEISSMAN JONATHAN S

IPC: C12N9/22 ,  C12N15/10 ,  C12N15/63

CPC classification number: C12N15/1079 ,  C12N15/102 ,  C12N15/1082 ,  C12N15/63 ,  C12Q1/6897

Abstract: Methods, compositions, and kits are provided for CRISPR/Cas mediated transcriptional modulation.

公开(公告)号：EP3328187A1

公开(公告)日：2018-06-06

申请号：EP16831304.7

申请日：2016-07-27

Applicant: Monsanto Technology LLC

Inventor： BOWEN, David, J. ,  CHAY, Catherine, A. ,  FLASINSKI, Stanislaw ,  YIN, Yong

IPC: A01H5/00 ,  A01N63/02 ,  C07K14/195 ,  C12N15/31 ,  C12N15/82

CPC classification number: C12N15/8286 ,  A01N37/46 ,  A01N63/02 ,  C07K14/325 ,  C12Q1/6897 ,  Y02A40/162

Abstract: A pesticidal protein class exhibiting toxic activity against Coleopteran, Lepidopteran, and Hemipteran pest species is disclosed, and includes, but is not limited to, TIC5290. DNA constructs are provided which contain a recombinant nucleic acid sequence encoding the TIC5290 pesticidal protein. Transgenic plants, plant cells, seed, and plant parts resistant to Lepidopteran, Coleopteran and Hemipteran infestation are provided which contain recombinant nucleic acid sequences encoding the TIC5290 pesticidal protein of the present invention. Methods for detecting the presence of the recombinant nucleic acid sequences or the protein of the present invention in a biological sample, and methods of controlling Coleopteran, Lepidopteran, and Hemipteran species pests using the TIC5290 pesticidal protein are also provided.

公开(公告)号：EP3204014A4

公开(公告)日：2018-05-30

申请号：EP15848249

申请日：2015-10-09

Applicant: GOVERNING COUNCIL UNIV TORONTO

Inventor： GRAY-OWEN SCOTT ,  GAUDET RYAN ,  MALOTT REBECCA

IPC: A61K31/7024 ,  A61K39/39 ,  A61P29/00 ,  A61P31/00 ,  A61P31/18 ,  A61P33/00 ,  A61P35/00 ,  A61P37/02 ,  C07H11/04 ,  C12Q1/00 ,  G01N33/48

CPC classification number: A61K39/39 ,  A61K31/7024 ,  A61K39/095 ,  A61K45/06 ,  A61K2039/55511 ,  C07H11/04 ,  C12Q1/6876 ,  C12Q1/6897 ,  C12Q2600/136 ,  C12Q2600/178 ,  G01N33/502 ,  Y02A50/403 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/423 ,  A61K2300/00

Abstract: Novel methods and uses for modulating immune responses are provided. The methods and uses involve the use of a TIFA activator such heptose-1,7-5 bisphosphate or an analogue or derivative thereof. The methods may be used to activate, inhibit or otherwise modify an immune response so as to either prevent or treat infectious or inflammatory diseases or cancer. Also provided are methods to identify compounds capable of modulating immune responses.

公开(公告)号：EP3303622A1

公开(公告)日：2018-04-11

申请号：EP16728849.7

申请日：2016-05-24

Applicant: Roche Diagnostics GmbH ,  F. Hoffmann-La Roche AG

Inventor： BODNER, Micah ,  MARSDEN, Jeremiah ,  REY, Diego Ariel

IPC: C12Q1/68 ,  C12N1/20 ,  C12Q1/66

CPC classification number: C12Q1/6897 ,  C12N7/00 ,  C12N2795/10041 ,  C12N2795/10043 ,  C12Q1/04 ,  C12Q1/66 ,  C12Q1/689

Abstract: Disclosed herein are methods and compositions for determining the presence or absence of a mechanism of antimicrobial resistance in a sample.

公开(公告)号：EP2802334B1

公开(公告)日：2018-03-07

申请号：EP13736256.2

申请日：2013-01-14

Applicant: Bell Biosystems, Inc.

Inventor： BELL, Caleb B., III ,  BAZAROV, Alexey

IPC: C12N5/071 ,  C12N5/074 ,  C12N5/095 ,  C12N5/26 ,  C12N5/28

CPC classification number: C12N5/166 ,  C12N1/00 ,  C12N5/00 ,  C12N5/16 ,  C12N9/88 ,  C12N15/02 ,  C12N15/03 ,  C12Q1/6897 ,  C12Y406/01001

Abstract: The present invention relates to eukaryotic mammalian host cells comprising an artificial endosymbiont belonging to the class ±-Proteobacteria, wherein the host cell is selected from the group consisting of human cancer cells, inducible pluripotent stem (IPS) cells, hematopoietic stem cells, neural stem cells, epidermal neural crest stem cells, mammary stem cells, intestinal stem cells, mesenchymal stem cells, olfactory adult stem cells, testicular cells, and human cells found in the circulatory system.

公开(公告)号：EP2845909B1

公开(公告)日：2018-01-31

申请号：EP14195943.7

申请日：2007-12-21

Applicant: Gene Stream Pty Ltd.

Inventor： Leu, Marco Peter ,  Daly, John Michael

IPC: C12Q1/66

CPC classification number: C12Q1/66 ,  C12N9/0069 ,  C12N9/99 ,  C12Q1/6897 ,  C12Y113/12007 ,  Y10T436/182

Abstract: Disclosed herein are methods for determining the amount or activity of one or more luciferases and methods for measuring the luminescent signal generated by one or more luciferases in a sample, the methods comprising incubating the sample with a reactive substrate(s) of the luciferase(s) to be analysed and a reducing agent to inactivate a first luciferase, wherein the first luciferase, in its native form, is a secreted luciferase.