公开(公告)号：EP4434351A1

公开(公告)日：2024-09-25

申请号：EP22896106.6

申请日：2022-11-17

申请人： Industry-Academic Cooperation Foundation, Yonsei University

发明人： LEE, Yong Ho ,  KIM, Eun Ran

IPC分类号： A23K50/50 ,  A23K20/147 ,  A23K20/163 ,  A23K20/158 ,  A23K20/142

CPC分类号： A23K20/158 ,  A23K20/147 ,  A23K50/50 ,  A23K20/142 ,  A23K20/163

摘要： The present invention relates to a composition for inducing liver disease in a mammal and a mammal with a liver disease induced using the same. The animal model of the present invention has been found to be an excellent animal model in which fatty liver, hepatic fibrosis, and insulin resistance are evenly induced, and which successfully reproduces the progression of a series of severe liver diseases, from hepatitis and excessive fibrogenesis in liver tissue through tissue hardening (cirrhosis) to liver cancer, and reflects the characteristics of each stage with high reliability. Accordingly, the present invention may be useful as a means for developing a therapeutic agent for chronic liver disease as well as studying the molecular and circulatory mechanisms of each stage of liver disease.