公开(公告)号：EP4438051A1

公开(公告)日：2024-10-02

申请号：EP24159416.7

申请日：2024-02-23

申请人： Biome Inc. ,  Industry-Academic Cooperation Foundation, Yonsei University

发明人： YOON, Sang Sun ,  CHOI, Jun Yong ,  YOON, Mi Young ,  JEONG, Uk Jin

IPC分类号： A61K35/741 ,  A61K35/745 ,  A61P31/04 ,  A23L33/135 ,  A23K10/18

CPC分类号： A61K35/745 ,  A61K35/741 ,  A23L33/135 ,  A23K10/18 ,  A61P31/04

摘要： The present invention provides an antibacterial composition including two or more strains selected from the group consisting of Anaerostipes hadrus, Collinsella aerofaciens, Blautia wexlerae and Bifidobacterium longum strains that inhibit the activity of antibiotic-resistant bacteria.

公开(公告)号：EP4332242A1

公开(公告)日：2024-03-06

申请号：EP22796218.0

申请日：2022-04-29

申请人： Industry-Academic Cooperation Foundation, Yonsei University

发明人： CHEONG, Jae-Ho ,  KIM, Jae-woo ,  YOON, Bo Kyung

IPC分类号： C12Q1/6886 ,  G01N33/574

摘要： A composition and method according to the present invention may be very effectively used to diagnose malignant gastric cancer and predict the prognosis of gastric cancer.

公开(公告)号：EP4295811A2

公开(公告)日：2023-12-27

申请号：EP22756441.6

申请日：2022-02-14

申请人： Industry-Academic Cooperation Foundation Yonsei University

发明人： KIM, Jong Eun

IPC分类号： A61C19/05 ,  A61C7/00 ,  G16H50/50 ,  G16H30/00 ,  G16H20/30 ,  G16H10/60 ,  G06N3/08 ,  A61C9/00 ,  G06T7/00

摘要： An occlusal plane suggestion method according to an embodiment of the present invention comprises the steps in which: (a) an occlusal plane suggestion device receives at least one of first to fourth data for a person with normal occlusion and matches same to generate IVth image data; (b) the occlusal plane suggestion device analyzes the generated IVth image data to learn the relationship between a landmark, which is an anatomical singularity, and the occlusal plane of the person with normal occlusion; (c) the occlusal plane suggestion device receives at least one of first to fourth data about a patient; and (d) the occlusal plane suggestion device analyzes the received at least one of the first to fourth data about the patient on the basis of the learned relationship between the landmark and the normal occlusal plane to suggest and output an occlusal plane optimized for the patient.

公开(公告)号：EP4292592A1

公开(公告)日：2023-12-20

申请号：EP22753001.1

申请日：2022-02-10

申请人： Industry-Academic Cooperation Foundation, Yonsei University ,  Arontier Co., Ltd.

发明人： KU, Cheol Ryong ,  KANG, Chan Woo ,  WANG, Eun Kyung ,  OH, Ju Hun ,  HONG, Zhenyu ,  SOHN, Insuk ,  KANG, Un Ho

IPC分类号： A61K31/215 ,  A61P3/00 ,  A61P9/10 ,  A61P1/16 ,  A23L33/10

摘要： The present invention relates to a composition for regulating glucose that regulates the amount of glucose metabolized in the small intestine. According to the present invention, it is possible to improve glucose metabolism in the small intestine and to promote blood glucose excretion into feces, thus lowering blood glucose concentration, thereby preventing, alleviating or treating metabolic disease.

公开(公告)号：EP4286376A1

公开(公告)日：2023-12-06

申请号：EP22781692.3

申请日：2022-04-01

申请人： Therapex Co., Ltd. ,  Industry-Academic Cooperation Foundation, Yonsei University

发明人： SIM, Tae Bo ,  CHO, Byoung Chul ,  CHO, Han Na ,  SENGUPTA, Sandip ,  MALLA REDDY, Gannarapu ,  KIM, Young Hoon

IPC分类号： C07D401/12 ,  A61K31/506 ,  A61K31/5377 ,  A61P35/00 ,  C07D401/14 ,  C07D405/14

摘要： The present invention relates to a pharmaceutical composition for preventing and treating a cancer disease, including lung cancer, caused by abnormal cell growth containing a novel trisubstituted pyrimidine derivative with inhibitory activity against protein kinases, including EGFR, and a pharmaceutically acceptable salt thereof as active ingredients. The novel compound of the present invention has strong inhibitory activity against protein kinases. Particularly, the novel compound of the present invention has potent inhibitory effects against various drug-resistant EGFR mutants (including exon 19 deletion-T790M-C797S-EGFR, L858R-T790M-C797S-EGFR, exon 19 deletion-T790M-EGFR, and L858R-T790M-EGFR) and is useful as a prophylactic and therapeutic agent for cancer diseases caused by these EGFR mutants.

公开(公告)号：EP4108766A1

公开(公告)日：2022-12-28

申请号：EP21757937.4

申请日：2021-02-15

申请人： Industry-Academic Cooperation Foundation, Yonsei University

发明人： KIM, Baek Gil ,  JANG, Yeonsue ,  CHO, Nam Hoon ,  KANG, Suki

IPC分类号： C12N5/09 ,  C12N5/071 ,  C12M3/00

摘要： The present invention relates to a method for producing a fibrosis-encapsulated tumoroid (FET), and the use of the fibrosis-encapsulated tumoroid. According to the present invention, an analogue that is close to real solid cancer tissue is produced using induced pluripotent stem cell-derived cell. The analogue has significant improvement over conventional tumoroids, which fail to perfectly reflect the characteristics of human solid cancer and have a very high probability of failure in the clinical validation stage. Thus, the present invention is expected to be widely used in the fields of new anticancer drug development and precision medicine.

公开(公告)号：EP3919888A3

公开(公告)日：2022-05-04

申请号：EP21175258.9

申请日：2021-05-21

申请人： Industry-Academic Cooperation Foundation, Yonsei University

发明人： KIM, Yong-Jun ,  KWON, Hong-Beom

IPC分类号： G01N15/02 ,  B03C3/017 ,  B03C3/02 ,  B03C3/47 ,  G01N15/06 ,  G01N27/02 ,  G01N27/66 ,  G01N27/70 ,  G01N1/22 ,  B01D57/02 ,  B03C3/38 ,  B03C3/12 ,  B03C3/41

摘要： A particle matter analysis device, an analysis method and a manufacturing method are disclosed. The particle matter analysis device includes a charger configured to receive power from a power supply device and to charge particles included in intaken air, an electrophoretic mobility particle collector configured to collect particles having electrophoretic mobility greater than a predetermined electrophoretic mobility among the charged particles based on an electrophoretic mobility and to measure a current of electrophoretic mobility particles, an aerodynamic particle collector configured to collect charged particles passing through the electrophoretic mobility particle collector based on an inertial force of the charged particles and to measure a current of aerodynamic particles, a filter configured to collect charged particles passing through the aerodynamic particle collector and to measure a current of filtered particles, and a processor, wherein the processor calculates a density of the particles based on a ratio of the current of electrophoretic mobility particles, the current of aerodynamic particles, and the current of filtered particles.

公开(公告)号：EP3967652A1

公开(公告)日：2022-03-16

申请号：EP20211720.6

申请日：2020-12-03

申请人： Industry-Academic Cooperation Foundation, Yonsei University

发明人： SHIM, Woo-young ,  KIM, Tae-young

IPC分类号： B82Y30/00 ,  B82Y40/00 ,  C01G28/00 ,  C30B29/40 ,  C30B29/68 ,  H01L21/02 ,  C30B23/00 ,  C30B29/10 ,  C30B29/60 ,  C30B29/64 ,  C30B33/06 ,  C30B33/10

摘要： Provided are a layered compound having indium and arsenic, a nanosheet that may be prepared using the same, and an electrical device including the materials. Provided is a layered compound represented by [Formula 1] Na 1-x In y As z (0≤x

公开(公告)号：EP3949913A1

公开(公告)日：2022-02-09

申请号：EP20778610.4

申请日：2020-03-25

申请人： Sungkwang Medical Foundation ,  Industry-Academic Cooperation Foundation, Yonsei University

发明人： SUNG, Jung Hoon ,  JUNG, Bo Young ,  YANG, Pil Sung

IPC分类号： A61F2/844 ,  A61L31/16 ,  A61L31/14 ,  A61F2/958 ,  A61B17/00 ,  A61F2/00 ,  A61K47/69

摘要： The present invention provides a drug-eluting stent. The present invention includes a main structure, and a drug delivery layer that is applied to the main structure and includes a fibrosis drug, wherein, when the main structure comes into contact with a target tissue, the fibrosis drug of the drug delivery layer is released into the target tissue to perform fibrous of the target tissue.

公开(公告)号：EP3882338A1

公开(公告)日：2021-09-22

申请号：EP19876188.4

申请日：2019-10-25

申请人： Industry-Academic Cooperation Foundation, Yonsei University ,  University Industry Foundation, Yonsei University Wonju Campus

发明人： LEE, Hong Jai ,  KIM, Soo Ki ,  MOON, Jae Seung ,  SHIN, Bo Young ,  LEE, Sang Kyou ,  SHIN, Jin Su

IPC分类号： C12N5/071 ,  C12N7/00 ,  G01N33/50 ,  A01K67/027

摘要： The present invention relates to a method for producing virus-infected cell line or animal model. According to the present invention, for a human-derived lipid layer of a virus, a bile acid or a bile acid derivative allows the lipid layer to be replaced with a target animal model-derived lipid layer; and this makes it possible to produce a virus-infected animal model that can be effectively used clinically without limitation resulting from species specificity. Furthermore, in the method for producing a cell line, viruses are mixed with a bile acid or a bile acid derivative and the mixture is used to treat a culture medium of a cell line, so that a cell line infected with a very high level of the viruses can be obtained. In addition, use of the method for producing a cell line of the present invention allows viruses to infect cell lines derived from various species and organs without limitation resulting from the viral species specificity and the restraining force related to the viral specific tissue or organ tropism.