公开(公告)号：EP4112714A1

公开(公告)日：2023-01-04

申请号：EP21199958.6

申请日：2021-09-29

申请人： Instituto Politécnico De Leiria

发明人： RODRIGUES PASCOAL FARIA, PAULA CRISTINA ,  FERNANDES ALVES, NUNO MANUEL ,  MONTEIRO DE MOURA, CARLA SOFIA ,  ALMEIDA MENESES, JOÃO PEDRO

IPC分类号： C12M3/04 ,  C12M1/12 ,  C12M1/36

摘要： The present invention describes an integrated bioreactor system (1), which comprises an external component (2), an internal component (3) and a support structure (4) which comprises a computational platform for control, learning and optimization of stimuli application.
The present invention further describes a process for the control, learning and monitoring of cell culture using the referred integrated bioreactor system (1), which allows the optimization of the application of different stimuli to cells placed in three-dimensional models (36) located in the internal component (3), to mimic the native conditions of the biological tissue.
This invention solves the problems referring to the need to optimize, control and monitor, in real time, the parameters involved in the stimulation of different cells in tissue engineering applications, thus reducing the time involved in differentiation and / or proliferation process, that are parameterizable for different cell lines.