公开(公告)号：EP4368214A1

公开(公告)日：2024-05-15

申请号：EP22211646.9

申请日：2022-12-06

申请人： Instituto Politécnico De Leiria

发明人： FERNANDES PATRÍCIO, TATIANA MARISA ,  DOS SANTOS MATEUS, ARTUR JORGE ,  FERNANDES ALVES, NUNO MANUEL ,  REIS MARQUES, HUGO FILIPE

IPC分类号： A61L27/42 ,  B33Y10/00 ,  B33Y80/00

CPC分类号： A61L27/425 ,  A61L2430/0220130101 ,  B33Y10/00 ,  B33Y80/00

摘要： The invention describes an intelligent three-dimensional biomimetic structure and the use thereof in the regeneration of bone tissue after a trauma or cancer situation.
Said intelligent three-dimensional biomimetic structure is comprised of filaments constituted by polymers mineralized with hydroxyapatite, which are able to mimic the bone tissue in terms of composition, morphology, and mechanical properties.

公开(公告)号：EP4112714A1

公开(公告)日：2023-01-04

申请号：EP21199958.6

申请日：2021-09-29

申请人： Instituto Politécnico De Leiria

发明人： RODRIGUES PASCOAL FARIA, PAULA CRISTINA ,  FERNANDES ALVES, NUNO MANUEL ,  MONTEIRO DE MOURA, CARLA SOFIA ,  ALMEIDA MENESES, JOÃO PEDRO

IPC分类号： C12M3/04 ,  C12M1/12 ,  C12M1/36

摘要： The present invention describes an integrated bioreactor system (1), which comprises an external component (2), an internal component (3) and a support structure (4) which comprises a computational platform for control, learning and optimization of stimuli application.
The present invention further describes a process for the control, learning and monitoring of cell culture using the referred integrated bioreactor system (1), which allows the optimization of the application of different stimuli to cells placed in three-dimensional models (36) located in the internal component (3), to mimic the native conditions of the biological tissue.
This invention solves the problems referring to the need to optimize, control and monitor, in real time, the parameters involved in the stimulation of different cells in tissue engineering applications, thus reducing the time involved in differentiation and / or proliferation process, that are parameterizable for different cell lines.

公开(公告)号：EP4382281A1

公开(公告)日：2024-06-12

申请号：EP22212802.7

申请日：2022-12-12

申请人： Instituto Politécnico De Leiria

发明人： FERNANDES ALVES, NUNO MANUEL ,  RODRIGUES PASCOAL FARIA, PAULA CRISTINA ,  ABREU VALENTE, JOANA FILIPA ,  ROSA DIAS, JULIANA ,  FERNANDES PATRICIO, TATIANA MARISA ,  DA SILVA BISCAIA, SARA ISABEL ,  DA SILVA CARREIRA, PEDRO JOSÉ

IPC分类号： B29C64/106 ,  B29C64/118 ,  B29C64/209 ,  B29C64/227 ,  B29C64/25 ,  B29C64/336 ,  B29C64/364 ,  B29C64/393 ,  B33Y30/00 ,  B33Y50/02 ,  B33Y70/10 ,  B29C64/379 ,  B33Y40/20

CPC分类号： B29C64/106 ,  B29C64/118 ,  B29C64/25 ,  B29C64/227 ,  B29C64/336 ,  B29C64/393 ,  B29C64/209 ,  B33Y30/00 ,  B33Y70/10 ,  B33Y50/02 ,  B29C64/364 ,  B29C64/379 ,  B33Y40/20

摘要： The present invention describes an integrated biomanufacturing system (5), which comprises four modules, namely: a bioextrusion module (1), an automatic monitoring module (2) in situ, an electrospinning module (3), and a culture module (4) in vitro with bioreactor.