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公开(公告)号：EP1097721A3
公开(公告)日：2001-05-23
申请号：EP00123909.4
申请日：2000-11-03
IPC分类号： A61K9/113
CPC分类号： A61K9/113
摘要： The present invention provides a W/O/W type oil adjuvant vaccine containing an outer aqueous phase containing 0.5 wt% - 20 wt% of a polyethylene glycol derivative having a molecular weight of 400 - 20,000, and an inner aqueous phase containing a biologically acceptable and effective amount of an antigen. The constitution of the present invention that a polyethylene glycol derivative having a specific molecular weight is contained in the outer aqueous phase enables preparation of a W/O/W type oil adjuvant vaccine showing a high adjuvant effect, reduced side effects such as topical response, superior preparation stability and superior workability to allow a person to give an injection easily due to the lowered viscosity.
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公开(公告)号：EP0781559B1
公开(公告)日：2007-02-07
申请号：EP96308676.4
申请日：1996-11-29
CPC分类号： A61K39/39 , A61K2039/55566 , Y10S514/937 , Y10S514/938 , Y10S514/939 , Y10S514/943
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公开(公告)号：EP1097721A2
公开(公告)日：2001-05-09
申请号：EP00123909.4
申请日：2000-11-03
IPC分类号： A61K47/00
CPC分类号： A61K9/113
摘要： The present invention provides a W/O/W type oil adjuvant vaccine containing an outer aqueous phase containing 0.5 wt% - 20 wt% of a polyethylene glycol derivative having a molecular weight of 400 - 20,000, and an inner aqueous phase containing a biologically acceptable and effective amount of an antigen. The constitution of the present invention that a polyethylene glycol derivative having a specific molecular weight is contained in the outer aqueous phase enables preparation of a W/O/W type oil adjuvant vaccine showing a high adjuvant effect, reduced side effects such as topical response, superior preparation stability and superior workability to allow a person to give an injection easily due to the lowered viscosity.
摘要翻译： 本发明提供W / O / W型油佐剂疫苗，其含有含有0.5重量％〜20重量％的分子量为400〜20,000的聚乙二醇衍生物的外水相和含有生物学上可接受的 和有效量的抗原。 在外层水相中含有具有特定分子量的聚乙二醇衍生物的本发明的构成使得能够制备显示出高佐剂效果的W / O / W型油佐剂疫苗，减少了局部应答等副作用， 优异的制备稳定性和优异的可加工性使得人能够由于粘度降低而容易地进行注射。
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公开(公告)号：EP0781559A2
公开(公告)日：1997-07-02
申请号：EP96308676.4
申请日：1996-11-29
CPC分类号： A61K39/39 , A61K2039/55566 , Y10S514/937 , Y10S514/938 , Y10S514/939 , Y10S514/943
摘要： A water-in-oil type oil adjuvant vaccine comprises 20 to 90% by weight of an oil phase A) which is in a liquid state at ordinary temperature; 0.5 to 30% by weight of an emulsifying agent comprising a non-ionic surfactant B) which is a partial ester derived from a polyhydric alcohol carrying at least three hydroxyl groups and a fatty acid and which is in a liquid state at 40°C and a polyoxyethylene (20 to 60 moles) hydroxy fatty acid triglyceride C); and 5 to 75% by weight of an aqueous phase D) containing a biologically acceptable and effective amount of antigens, and optionally E) 0.01 to 10% by weight of an amino acid or a salt thereof and 0.01 to 10% by weight of a nonreducing sugar or a sugar alcohol having at least 5 hydroxyl groups in the molecule. In addition, a water-in-oil-in-water type oil adjuvant vaccine comprises the foregoing water-in-oil type oil adjuvant vaccine as an internal phase and an outer aqueous phase F) comprising 0.2 to 20% by weight of an emulsifying agent which comprises a non-ionic surfactant and which has an overall HLB value of not less than 10. The oil adjuvant vaccines show a high ability to induce an antibody-production over a long period of time and are excellent in requirements for medicines such as stability and safety.
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