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    Oil adjuvant vaccine and method for preparing same
    2.
    发明公开
    Oil adjuvant vaccine and method for preparing same 失效
    Öladjuvierter疫苗和工艺及其制备方法

    公开(公告)号：EP0781559A2

    公开(公告)日：1997-07-02

    申请号：EP96308676.4

    申请日：1996-11-29

    申请人： Juridical Foundation, The Chemo-Sero-Therapeutic Research Institute

    发明人： Miyahara, Tokuji ,  Takase, Kozo ,  Saito, Koichi ,  Kishimoto, Yoko ,  Tokuyama, Satoru

    IPC分类号： A61K39/39 ,  A61K9/113

    CPC分类号： A61K39/39 ,  A61K2039/55566 ,  Y10S514/937 ,  Y10S514/938 ,  Y10S514/939 ,  Y10S514/943

    摘要： A water-in-oil type oil adjuvant vaccine comprises 20 to 90% by weight of an oil phase A) which is in a liquid state at ordinary temperature; 0.5 to 30% by weight of an emulsifying agent comprising a non-ionic surfactant B) which is a partial ester derived from a polyhydric alcohol carrying at least three hydroxyl groups and a fatty acid and which is in a liquid state at 40°C and a polyoxyethylene (20 to 60 moles) hydroxy fatty acid triglyceride C); and 5 to 75% by weight of an aqueous phase D) containing a biologically acceptable and effective amount of antigens, and optionally E) 0.01 to 10% by weight of an amino acid or a salt thereof and 0.01 to 10% by weight of a nonreducing sugar or a sugar alcohol having at least 5 hydroxyl groups in the molecule. In addition, a water-in-oil-in-water type oil adjuvant vaccine comprises the foregoing water-in-oil type oil adjuvant vaccine as an internal phase and an outer aqueous phase F) comprising 0.2 to 20% by weight of an emulsifying agent which comprises a non-ionic surfactant and which has an overall HLB value of not less than 10. The oil adjuvant vaccines show a high ability to induce an antibody-production over a long period of time and are excellent in requirements for medicines such as stability and safety.