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公开(公告)号：EP1253145B1
公开(公告)日：2006-09-20
申请号：EP01948982.2
申请日：2001-01-30
发明人： OHNODA, Michiro , ORITA, Kazuo , YOSHIDA, Noriyuki
IPC分类号： C07D277/34 , A61K31/426
CPC分类号： C07D277/34
摘要： A method of industrially advantageously purifying 5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[4-(trifluoromethyl)phenylmethyl]benzamide (KRP-297), which improves insulin resistance and is highly effective in lowering blood sugar and in lipid diminution. The method comprises the steps of: forming an alkali metal salt of KRP-297 and a hydrate thereof in a reaction system for producing KRP-297; isolating and purifying them; and then liberating the KRP-297 from the salt. Also provided are an alkali metal salt of KRP-297 and a hydrate of the salt.
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公开(公告)号：EP1253145A1
公开(公告)日：2002-10-30
申请号：EP01948982.2
申请日：2001-01-30
发明人： OHNODA, Michiro , ORITA, Kazuo , YOSHIDA, Noriyuki
IPC分类号： C07D277/34
CPC分类号： C07D277/34
摘要： The invention provides alkali metal salt of 5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy- N -[[4-(trifluoromethyl) phenyl]methyl]benzamide and its hydrate. A method has been found, wherein, upon preparing KRP-297, the alkali metal salt of KRP-297 and its hydrate are formed in the reaction system and, after separation and purification, they are freed again from salt, thereby KRP-297 can be advantageously purified industrially for preparation.
摘要翻译： 本发明提供了5-Ä（2,4-二氧代噻唑烷-5-基）甲基-2-甲氧基-N-哒嗪-3-基（三氟甲基）苯基Ü甲基苯甲酰胺及其水合物的碱金属盐。 已经发现一种方法，其中在制备KRP-297时，在反应体系中形成KRP-297的碱金属盐及其水合物，分离和纯化后，再次从盐中释放出来，从而KRP-297可以 有利地在工业上纯化用于制备。
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