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    Process for producing n-glycyltyrosine
    2.
    发明公开
    Process for producing n-glycyltyrosine 有权
    Verfahren zur Herstellung von Glycyltyrosin

    公开(公告)号：EP0950664A1

    公开(公告)日：1999-10-20

    申请号：EP99107190.3

    申请日：1999-04-13

    申请人： KYOWA HAKKO KOGYO CO., LTD.

    发明人： Mimura, Takashi ,  Imai, Eiichiro ,  Imai, Takahiro ,  Ogasa, Takehiro ,  Kasai, Masaji

    IPC分类号： C07K5/06 ,  C07C233/47

    CPC分类号： C07K5/06026 ,  C07C233/47

    摘要： Provided is a process for efficiently producing N-glycyltyrosine of high purity represented by the following formula:
    a salt thereof, or a solvate thereof, which comprises adding dropwise to an aqueous suspension of tyrosine or a salt thereof 2 equivalents or more of a haloacetyl halide and an aqueous solution of an inorganic base simultaneously in the presence or absence of an organic solvent, and subjecting the resulting N-haloacetyltyrosine to a reaction with an ammonium ion. Also provided are N-glycyl-L-tyrosine dihydrate having the crystal structures showing specific diffraction patterns in X-ray powder diffraction and processes for producing the same which are characterized by comprising crystallizing the dihydrate from an ethanol-water mixed solvent or water.

    摘要翻译： 本发明提供了一种高效纯化由下式表示的高纯度N-甘氨酰酪氨酸的方法：其盐或其溶剂化物，其包括将2当量或更多的酪氨酸或其盐的水悬浮液滴加到 卤代乙酰卤和无机碱的水溶液同时在有机溶剂存在或不存在下进行，并使所得的N-卤代乙酰基酪氨酸与铵离子反应。 还提供了具有在X射线粉末衍射中显示特定衍射图案的晶体结构的N-甘氨酰-L-酪氨酸二水合物及其制备方法，其特征在于包括从乙醇 - 水混合溶剂或水中结晶二水合物。