公开(公告)号：EP0744409A4

公开(公告)日：1998-09-09

申请号：EP95909967

申请日：1995-02-23

申请人： KYOWA HAKKO KOGYO KK

发明人： YAMASAKI MOTOO ,  OKABE MASAMI ,  SUZAWA TOSHIYUKI ,  KOBAYASHI KEN ,  MARUYAMA KUMIKO

IPC分类号： A61K38/00 ,  C07K14/535 ,  A61K38/19

CPC分类号： C07K14/535 ,  A61K38/00

摘要： A human granulocyte-colony stimulating polypeptide wherein at least one amino, carboxy, mercapto or guanidino group has been chemically modified by a chemical modifier; a platelet growth accelerator containing the polypeptide; a method of treating thrombocytopenic patients by administering an efficacious dose of the polypeptide; the use of the polypeptide for producing a pharmacological composition efficacious in treating thrombocytopenic patients; and a composition for treating thrombocytopenic patients comprising an efficacious dose of the polypeptide in a pharmacologically acceptable dosage form together with a pharmacologically acceptable carrier.

公开(公告)号：EP0921131A4

公开(公告)日：2002-11-27

申请号：EP98923147

申请日：1998-06-05

申请人： KYOWA HAKKO KOGYO KK

发明人： YAMASAKI MOTOO ,  SUZAWA TOSHIYUKI ,  KOBAYASHI KEN ,  KONISHI NOBORU ,  AKINAGA SHIRO ,  MARUYAMA KUMIKO

IPC分类号： A61K38/00 ,  C07K1/107 ,  C07K14/535 ,  C07K1/113 ,  A61K38/16 ,  A61K38/19 ,  A61K47/48

CPC分类号： C07K1/1077 ,  A61K38/00 ,  C07K14/535

摘要： Chemically modified polypeptides wherein at least one of the hydroxyl groups of a polypeptide molecule has been modified with polyalkylene glycols; a process for producing these polypeptides; a therapeutic method with the use of these polypeptides; the use of these polypeptides; drugs containing these polypeptides; and therapeutic compositions containing these polypeptides.