公开(公告)号：EP0921131A4

公开(公告)日：2002-11-27

申请号：EP98923147

申请日：1998-06-05

申请人： KYOWA HAKKO KOGYO KK

发明人： YAMASAKI MOTOO ,  SUZAWA TOSHIYUKI ,  KOBAYASHI KEN ,  KONISHI NOBORU ,  AKINAGA SHIRO ,  MARUYAMA KUMIKO

IPC分类号： A61K38/00 ,  C07K1/107 ,  C07K14/535 ,  C07K1/113 ,  A61K38/16 ,  A61K38/19 ,  A61K47/48

CPC分类号： C07K1/1077 ,  A61K38/00 ,  C07K14/535

摘要： Chemically modified polypeptides wherein at least one of the hydroxyl groups of a polypeptide molecule has been modified with polyalkylene glycols; a process for producing these polypeptides; a therapeutic method with the use of these polypeptides; the use of these polypeptides; drugs containing these polypeptides; and therapeutic compositions containing these polypeptides.

公开(公告)号：EP0783003A4

公开(公告)日：1998-01-07

申请号：EP96912262

申请日：1996-04-26

申请人： KYOWA HAKKO KOGYO KK

发明人： YOKOI HARUHIKO ,  SHIOTSU YUKIMASA ,  KONISHI NOBORU ,  ANAZAWA HIDEHARU ,  TAMAOKI TATSUYA ,  YAMASAKI MOTOO ,  TERASAKI YOKO ,  UCHIDA KAZUHISA ,  YAMASHITA KINYA

IPC分类号： A61K38/00 ,  C07K14/52 ,  C07K14/535 ,  C07K19/00 ,  A61K38/19 ,  C12N15/62

CPC分类号： C07K14/535 ,  A61K38/00 ,  C07K14/52 ,  C07K14/524 ,  C07K2319/00

摘要： A fused polypeptide composed of a polypeptide having the G-CSF activity with another polypeptide having the TPO activity; a DNA encoding this fused polypeptide; a fused polypeptide wherein a polypeptide having the G-CSF activity has been fused with another polypeptide having the TPO activity via a spacer peptide; a DNA encoding this fused polypeptide; a polypeptide wherein the above-mentioned fused polypeptide composed of the polypeptide having the G-CSF activity with the polypeptide having the TPO activity has been further chemically modified with a polyalkylene glycol derivative; and a remedy for anemia containing such a fused polypeptide as the active ingredient.