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    COMPOUND FOR GENERATING SECOND HARMONIC OF LIGHT, DYE COMPOSITION FOR GENERATING SECOND HARMONIC OF LIGHT, AND CELL EXAMINATION METHOD
    1.
    发明公开
    COMPOUND FOR GENERATING SECOND HARMONIC OF LIGHT, DYE COMPOSITION FOR GENERATING SECOND HARMONIC OF LIGHT, AND CELL EXAMINATION METHOD 有权
    用于产生二次谐波的化合物，用于产生二次谐波的染料组合物以及细胞检查方法

    公开(公告)号：EP3000848A1

    公开(公告)日：2016-03-30

    申请号：EP14801474.9

    申请日：2014-05-23

    申请人： Keio University ,  University of Tsukuba

    发明人： NURIYA, Mutsuo ,  YASUI, Masato ,  ARAI, Tatsuo ,  MOMOTAKE, Atsuya ,  FUKUSHIMA, Syun

    IPC分类号： C09B44/12 ,  C09B67/20 ,  C12Q1/04 ,  G01N21/64 ,  C09B29/036 ,  C09B29/08

    CPC分类号： G01N33/5091 ,  C09B29/0048 ,  C09B29/0803 ,  C09B29/0805 ,  C09B29/081 ,  C09B29/3639 ,  C09B44/126 ,  G01N21/636

    摘要： Provided are a compound that generates an SHG signal but has suppressed generation of a TPF signal. Also provided is a cell examination method using the same. A compound for generating a second harmonic of light, the compound being an azobenzene derivative of formula (1), or a salt thereof. (R 1 and R 2 independently represent alkyl groups having 6-12 carbon atoms, and R 3 to R 18 independently represent substituents selected from hydrogen, halogens, alkyl groups, alkoxy groups, aryl groups, amino groups, hydroxyl groups, nitro groups, and cyano groups, R 5 and R 6 , R 9 and R 10 , R 13 and R 14 , and R 17 and R 18 may combine together and form a ring structure having 5-7 carbon atoms. X represents -N + R 19 R 20 R 21 , a sulfonyl group, a carboxyl group, or an -OR group. Here, R 19 , R 20 , and R 21 independently represent straight-chain or branched alkyl groups having 1-5 carbon atoms, and -OR represents a monovalent polyalkylene oxide group terminated by an alkoxy group. a is 0 or 1, b is 0 or 1, and n is an integer of 1-10.)

    摘要翻译： 提供了产生SHG信号但抑制了TPF信号的产生的化合物。 还提供了使用其的细胞检查方法。 一种用于产生光的二次谐波的化合物，该化合物是式（1）的偶氮苯衍生物或其盐。 （R1和R2独立地表示具有6-12个碳原子的烷基，并且R3至R18独立地表示选自氢，卤素，烷基，烷氧基，芳基，氨基，羟基，硝基和氰基的取代基， R5和R6，R9和R10，R13和R14以及R17和R18可以结合在一起形成具有5-7个碳原子的环结构，X代表-N + R19R20R21，磺酰基，羧基或-OR 此处，R 19，R 20和R 21分别独立地表示碳原子数为1〜5的直链或支链的烷基，-OR表示被烷氧基封端的1价聚亚烷基氧基，a为0或1，b为0 或1，并且n是1-10的整数。）

    SLEEP DETERMINING DEVICE, SLEEP DETERMINING METHOD, AND SLEEP DETERMINING PROGRAM
    5.
    发明公开
    SLEEP DETERMINING DEVICE, SLEEP DETERMINING METHOD, AND SLEEP DETERMINING PROGRAM 审中-公开

    公开(公告)号：EP3632322A1

    公开(公告)日：2020-04-08

    申请号：EP18809417.1

    申请日：2018-06-04

    申请人： Keio University

    发明人： MITSUKURA, Yasue ,  YASUI, Masato ,  FUKUNAGA Koichi ,  FURUKAWA Toshiharu

    IPC分类号： A61B5/16 ,  A61B5/0245

    摘要： An object of the present invention is to provide a sleep determination apparatus, a sleep determination method, and a sleep determination program that provide an accurate and detailed determination of a sleep stage.
    A sleep determination apparatus of the present invention comprising: a heart rate data obtaining means for obtaining, based on data regarding a heart rate of a body of a user, a very low frequency component (VLF), a ratio of a low frequency component (LF) to a high frequency component (HF), a mean heartbeat interval (RRI), and a standard deviation of each heartbeat interval (RRI) of the heart rate as heart rate variability parameters indicating a heart rate state; and a sleep state determining means for determining which of the first non-REM sleep stage or the second non-REM sleep stage the heart rate variability parameters of the user indicate, in accordance with a first determination condition that is set based on a correlation between the heart rate variability parameters and the first non-REM sleep stage and a second determination condition that is set based on a correlation between the heart rate variability parameters and the second non-REM sleep stage.