公开(公告)号：EP4403186A1

公开(公告)日：2024-07-24

申请号：EP22870048.0

申请日：2022-09-16

申请人： Keio University

发明人： YASUDA Hiroyuki ,  SATO Toshiro ,  EBISUDANI Toshiki ,  FUKUSHIMA Takahiro ,  FUKUNAGA Koichi ,  HAMAMOTO Junko

IPC分类号： A61K45/00 ,  A61P11/00 ,  A61P35/00 ,  C12N5/09 ,  C12N1/00 ,  G01N33/574 ,  A61K31/4985

CPC分类号： A61K31/4985 ,  A61K45/00 ,  A61P11/00 ,  A61P35/00 ,  C12N1/00 ,  C12N5/06 ,  G01N33/574

摘要： A therapeutic agent for small cell lung cancer containing an insulin-like growth factor 1 receptor (IGF1R) inhibitor as an active ingredient, and a method whether or not an administration of the therapeutic agent for small cell lung cancer patients is effective, including: a step of detecting the expression of YAP1 or its downstream factors in the cancer cells from the small cell lung cancer patient; and a step of detecting the expression of YAP1 or its downstream factors in the cancer cells from the small cell lung cancer patient, wherein when the expression level of YAP1 or the expression level of the downstream factor of YAP1 is significantly higher than that of a control, the administration of the therapeutic agent is effective in treating the patient with small cell lung cancer.

公开(公告)号：EP3632322A1

公开(公告)日：2020-04-08

申请号：EP18809417.1

申请日：2018-06-04

申请人： Keio University

发明人： MITSUKURA, Yasue ,  YASUI, Masato ,  FUKUNAGA Koichi ,  FURUKAWA Toshiharu

IPC分类号： A61B5/16 ,  A61B5/0245

摘要： An object of the present invention is to provide a sleep determination apparatus, a sleep determination method, and a sleep determination program that provide an accurate and detailed determination of a sleep stage.
A sleep determination apparatus of the present invention comprising: a heart rate data obtaining means for obtaining, based on data regarding a heart rate of a body of a user, a very low frequency component (VLF), a ratio of a low frequency component (LF) to a high frequency component (HF), a mean heartbeat interval (RRI), and a standard deviation of each heartbeat interval (RRI) of the heart rate as heart rate variability parameters indicating a heart rate state; and a sleep state determining means for determining which of the first non-REM sleep stage or the second non-REM sleep stage the heart rate variability parameters of the user indicate, in accordance with a first determination condition that is set based on a correlation between the heart rate variability parameters and the first non-REM sleep stage and a second determination condition that is set based on a correlation between the heart rate variability parameters and the second non-REM sleep stage.