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1.发明公开ASPALATHIN-ÄHNLICHES DIHYDROCHALCON, EXTRAKTE AUS UNFERMENTIERTEM ROTBUSCH UND VERFAHREN ZUR HERSTELLUNG 有权阿司巴汀相关二氢查耳酮，未发酵ROTBUSCH和方法提取用于生产
公开(公告)号：EP2069334A1
公开(公告)日：2009-06-17
申请号：EP08801873.4
申请日：2008-09-05
发明人： FRANK, Bruno , DIMPFEL, Wilfried
IPC分类号： C07D407/10 , A61K31/353 , A61P25/00
CPC分类号： C07D407/10
摘要： The present invention relates to a novel chemical compound of the formula (I) and to pharmaceutically acceptable salts, derivatives and esters thereof. In addition, the invention also relates to a process for isolating the compound of the formula (I) from raw rooibos material. The present invention likewise relates to a rooibos extract which has a content of the compound of the formula (I) of at least 0.4% by weight. The invention further relates to the use of the chemical compound of the formula (I) and to the pharmaceutically acceptable salts, derivatives and esters thereof, and of the inventive rooibos extract as a medicament, especially for treatment of neurological and psychiatric disorders of the central nervous system. The expression “pharmaceutically active” also includes those effects which lead to a subjective improvement in mental state, in which case approval under pharmaceutical legislation need not be absolutely necessary. The compound of the formula (I) is shown below: (formula I).
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2.发明授权
公开(公告)号：EP2320922B1
公开(公告)日：2012-10-17
申请号：EP09781684.7
申请日：2009-08-11
发明人： FRANK, Bruno
IPC分类号： A61K36/9066 , A61K36/258 , A61K36/82 , A61K36/48 , A61P25/28
CPC分类号： A61K36/48 , A61K36/258 , A61K36/82 , A61K36/9066 , A61K2300/00
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3.发明授权ASPALATHIN-ÄHNLICHES DIHYDROCHALCON, EXTRAKTE AUS UNFERMENTIERTEM ROTBUSCH UND VERFAHREN ZUR HERSTELLUNG 有权阿司巴汀相关二氢查耳酮，未发酵ROTBUSCH和方法提取用于生产
公开(公告)号：EP2069334B1
公开(公告)日：2011-11-16
申请号：EP08801873.4
申请日：2008-09-05
发明人： FRANK, Bruno , DIMPFEL, Wilfried
IPC分类号： C07D407/10 , A61K31/353 , A61P25/00
CPC分类号： C07D407/10
摘要： The present invention relates to a novel chemical compound of the formula (I) and to pharmaceutically acceptable salts, derivatives and esters thereof. In addition, the invention also relates to a process for isolating the compound of the formula (I) from raw rooibos material. The present invention likewise relates to a rooibos extract which has a content of the compound of the formula (I) of at least 0.4% by weight. The invention further relates to the use of the chemical compound of the formula (I) and to the pharmaceutically acceptable salts, derivatives and esters thereof, and of the inventive rooibos extract as a medicament, especially for treatment of neurological and psychiatric disorders of the central nervous system. The expression “pharmaceutically active” also includes those effects which lead to a subjective improvement in mental state, in which case approval under pharmaceutical legislation need not be absolutely necessary. The compound of the formula (I) is shown below: (formula I).
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4.发明公开
公开(公告)号：EP2320922A2
公开(公告)日：2011-05-18
申请号：EP09781684.7
申请日：2009-08-11
发明人： FRANK, Bruno
IPC分类号： A61K36/9066 , A61K36/258 , A61K36/82 , A61K36/48 , A61P25/28
CPC分类号： A61K36/48 , A61K36/258 , A61K36/82 , A61K36/9066 , A61K2300/00
摘要： The invention relates to combinations of extracts of various plants. A plant extract is obtained from non-fermented rooibos by extraction with a mixture of water and alcohol. The rooibos extract contains a compound of formula (I) (aspacat). The compound of formula (I) is shown below: (I). The extracts of other plants are obtained from fermented rooibos and/or green tea and/or curcuma and/or ginseng. The combinations can be used as drugs and/or food supplements for preventing and/or treating dementia disorders.
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