公开(公告)号：EP2291364A2

公开(公告)日：2011-03-09

申请号：EP09762685.7

申请日：2009-06-12

申请人： Korea Institute of Science and Technology ,  Hanmi Holdings Co., Ltd

发明人： KIM, Dong Jin ,  YOO, Kyung Ho ,  BYUN, Ji Hun ,  KIM, YoungSoo ,  KIM, Hye Yun ,  LEE, Gwan Sun ,  KIM, Maeng Sup ,  AHN, Young Gil ,  LEE, Ji Hoon ,  LEE, Myoung-Hwan ,  HWANG, Hana ,  RYU, Jiyeon

IPC分类号： C07D307/78 ,  A61K31/343

CPC分类号： C07D307/81 ,  C07D307/80

摘要： The present invention relates to a novel compound which efficiently inhibits the formation of beta-amyloid fibrils in the brain to be useful for preventing or treating a degenerative brain disease, a method for preparing same, and a pharmaceutical composition comprising same as an active ingredient.

摘要翻译： 本发明涉及有效抑制脑中β-淀粉样原纤维形成以用于预防或治疗退行性脑疾病的新型化合物，其制备方法，以及包含其作为活性成分的药物组合物。

公开(公告)号：EP4092029A1

公开(公告)日：2022-11-23

申请号：EP20913360.2

申请日：2020-07-14

申请人： Korea Institute of Science and Technology

发明人： SIM, Tae Bo ,  CHO, Han Na ,  CHOI, Seung Hye ,  HUR, Woo Young ,  SONG, Chi Man ,  LEE, Ji Hoon ,  LEE, Jung Yeol ,  PARK, Sun You ,  CHOI, Myeong A ,  JOO, Jeong Min

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P35/00

摘要： The present disclosure relates to a 7-amino-3,4-dihydropyrimidopyrimidin-2-one derivative compound exhibiting excellent anti-proliferative effects against cancer cells, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a stereoisomer thereof, a production method therefor, a pharmaceutical composition for preventing, alleviating or treating cancer metastasis and proliferative disease containing the same as an active ingredient, and an anti-cancer composition against cancer cells. The compound exhibits excellent cancer cell inhibitory activity and anti-proliferative effects, and thus is effective in inhibiting cancer cells, preventing cancer metastasis and proliferative diseases or treating cancer.