公开(公告)号：EP4092029A1

公开(公告)日：2022-11-23

申请号：EP20913360.2

申请日：2020-07-14

申请人： Korea Institute of Science and Technology

发明人： SIM, Tae Bo ,  CHO, Han Na ,  CHOI, Seung Hye ,  HUR, Woo Young ,  SONG, Chi Man ,  LEE, Ji Hoon ,  LEE, Jung Yeol ,  PARK, Sun You ,  CHOI, Myeong A ,  JOO, Jeong Min

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P35/00

摘要： The present disclosure relates to a 7-amino-3,4-dihydropyrimidopyrimidin-2-one derivative compound exhibiting excellent anti-proliferative effects against cancer cells, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a stereoisomer thereof, a production method therefor, a pharmaceutical composition for preventing, alleviating or treating cancer metastasis and proliferative disease containing the same as an active ingredient, and an anti-cancer composition against cancer cells. The compound exhibits excellent cancer cell inhibitory activity and anti-proliferative effects, and thus is effective in inhibiting cancer cells, preventing cancer metastasis and proliferative diseases or treating cancer.