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3 条记录 (耗时 0.009 秒)

    Dispersable dihydroergotoxin tablets
    1.
    发明公开
    Dispersable dihydroergotoxin tablets 失效
    可分散的双氢麦角新碱片剂

    公开(公告)号：EP0361354A1

    公开(公告)日：1990-04-04

    申请号：EP89117650.5

    申请日：1989-09-25

    申请人： LEK, tovarna farmacevtskih in kemicnih izdelkov, d.d.

    发明人： Milovac, Jenny ,  Kovacic, Mateja ,  Kopitar, Zdravko ,  Urbancic-Smerkolj, Janja ,  Lenardic, Andrej ,  Zorz, Mirjan ,  Kofler, Bojan ,  Vene-Mozina, Angela ,  Nikolic, Vida ,  Lampret, Marija ,  Meden, Breda

    IPC分类号： A61K31/48 ,  A61K9/20

    CPC分类号： A61K9/2059 ,  A61K9/2013 ,  A61K9/2027 ,  A61K9/2054 ,  A61K31/48

    摘要： There are described novel dispersible tablets of dihydroergotoxine or of acid addition salts thereof, containing 0.1 to 4 % by weight of dihydroergotoxine or its acid addition salts, 4 to 60 % by weight of one or more disintegrating agents, 0.8 to 10 % by weight of an organic acid and, optionally, 0.2 to 2 % by weight of an antioxidizing agent together with other common adjuvants.
    The process for the manufacture of dispersible tablets of dihydroergotoxine and of acid addition salts thereof is carried out on the basis of known methods by granulating the ingredients and by compressing the granulate to tablets.
    Dispersible tablets disintegrate within less than 1 minute when brought in contact with water at room temperature to yield a fine dispersion, which facilitates the oral applica­tion. Therefore such tablets are particulary suitable for the aged. Dispersible tablets containing dihydroergotoxine or acid addition salts thereof excell by their improved rate of dissolution and good bioavailability.

    摘要翻译： 描述了二氢麦角新碱或其酸加成盐的新型分散片剂，其含有0.1至4重量％的二氢麦角碱或其酸加成盐，4至60重量％的一种或多种崩解剂，0.8至10重量％ 有机酸和任选地0.2至2重量％的抗氧化剂以及其它常见助剂。 制备二氢麦角碱分散片及其酸加成盐的方法是在已知方法的基础上通过将各成分造粒并将颗粒压制成片剂来进行的。 当分散片在室温下与水接触时，在不到1分钟的时间内崩解，产生精细分散体，便于口服。 因此这种片剂特别适合老年人。 含有二氢麦角碱或其酸加成盐的分散片优于其溶解速率和良好的生物利用度。

    Dispersible cimetidine tablets
    3.
    发明公开
    Dispersible cimetidine tablets 失效
    Dispergierbare，Cimetidin enthaltende Tabletten。

    公开(公告)号：EP0347767A1

    公开(公告)日：1989-12-27

    申请号：EP89110951.4

    申请日：1989-06-16

    申请人： LEK, tovarna farmacevtskih in kemicnih izdelkov, d.d.

    发明人： Kovacic, Mateja ,  Milovac, Jenny ,  Cvelbar, Polona ,  Stalc, Anton ,  Trost, Zvezdana ,  Kopitar, Zdravko ,  Kofler, Bojan ,  Nikolic, Vida ,  Lampret, Marija ,  Lippai, Marija

    IPC分类号： A61K31/415 ,  A61K9/20

    CPC分类号： A61K31/415 ,  A61K9/2004 ,  A61K9/2013 ,  A61K9/2031

    摘要： There are described novel dispersible cimetidine tablets containing 30 to 90 % by weight of one of the polymorphous modifications of cimetidine A, B or C, 5 to 55 % by weight of one or more disintegrationg agents, 0.05 to 5.0 % by weight of a surfactant, such as sodium lauryl sulphate together with other common adjuvants.
    The process for the manufacture of dispersible cimetidine tablets is effected on the basis of known methods by granulating the ingredients and by compressing the granu­late to tablets.
    Dispersible tablets disintegrate when brought in contact with water at room tempera­ture within less than 1 minute to yield a fine dispersion, which facilitates the oral ap­plication. Therefore such tablets are particularly suitable for certain groups of patients, especiallly for the aged and children. Dispersible tablets containing cimetidine excell by their improved rate of dissolution and good bioavailability.

    摘要翻译： 描述了含有30至90重量％的西咪替丁A，B或C的多晶型修饰之一，5至55重量％的一种或多种崩解剂，0.05至5.0重量％的表面活性剂 ，如十二烷基硫酸钠以及其他常见佐剂。 基于已知方法制备分散西咪替丁片的方法是通过造粒成分并将颗粒压制成片剂而实现的。 当在小于1分钟内在室温下与水接触时，可分散的片剂产生细分散体，这有利于口服。 因此，这种片剂特别适用于某些患者群体，特别适合于老年人和儿童。 含有西咪替丁的分散片优于其改善的溶解速率和良好的生物利用度。