THIOARYL DERIVATIVES AS GPR120 AGONISTS
    1.
    发明公开
    THIOARYL DERIVATIVES AS GPR120 AGONISTS 审中-公开
    作为GPR120激动剂的噻吩衍生物

    公开(公告)号:EP2914580A1

    公开(公告)日:2015-09-09

    申请号:EP13852301.4

    申请日:2013-11-05

    摘要: The present invention relates to thioaryl derivatives of Formula 1 as defined in the specification, a method for preparing the same, a pharmaceutical composition comprising the same and use thereof. The thioaryl derivatives of Formula 1 according to the present invention promote GLP-1 formation in the gastrointestinal tract and improve insulin resistance in macrophages, pancreas cells, etc. due to anti-inflammatory action, and can accordingly be effectively used for preventing or treating diabetes, complications of diabetes, inflammation, obesity, non-alcoholic fatty liver, steatohepatitis or osteoporosis.

    摘要翻译: 本发明涉及说明书中定义的式1的硫代芳基衍生物,其制备方法,包含其的药物组合物及其用途。 根据本发明的式1的硫代芳基衍生物促进胃肠道中的GLP-1形成并由于抗炎作用而改善巨噬细胞,胰腺细胞等中的胰岛素抵抗,并且因此可以有效地用于预防或治疗糖尿病 ,糖尿病并发症,炎症,肥胖症,非酒精性脂肪肝,脂肪性肝炎或骨质疏松症。