公开(公告)号：EP2914580A1

公开(公告)日：2015-09-09

申请号：EP13852301.4

申请日：2013-11-05

申请人： LG Life Sciences Ltd.

发明人： KIM, Young Kwan ,  KIM, Myoung Yeol ,  PARK, Sang Yun ,  PARK, Ok Ku ,  ARTEMOV, Vasily ,  LEE, Sang Dae ,  JOO, Hyun Woo ,  CHOI, Eun Sil

IPC分类号： C07D213/80 ,  C07D241/18 ,  A61K31/44 ,  A61P3/10

CPC分类号： C07D213/70 ,  A61K31/44 ,  C07D213/80 ,  C07D241/18

摘要： The present invention relates to thioaryl derivatives of Formula 1 as defined in the specification, a method for preparing the same, a pharmaceutical composition comprising the same and use thereof. The thioaryl derivatives of Formula 1 according to the present invention promote GLP-1 formation in the gastrointestinal tract and improve insulin resistance in macrophages, pancreas cells, etc. due to anti-inflammatory action, and can accordingly be effectively used for preventing or treating diabetes, complications of diabetes, inflammation, obesity, non-alcoholic fatty liver, steatohepatitis or osteoporosis.

摘要翻译： 本发明涉及说明书中定义的式1的硫代芳基衍生物，其制备方法，包含其的药物组合物及其用途。 根据本发明的式1的硫代芳基衍生物促进胃肠道中的GLP-1形成并由于抗炎作用而改善巨噬细胞，胰腺细胞等中的胰岛素抵抗，并且因此可以有效地用于预防或治疗糖尿病 ，糖尿病并发症，炎症，肥胖症，非酒精性脂肪肝，脂肪性肝炎或骨质疏松症。