公开(公告)号：EP1743663A2

公开(公告)日：2007-01-17

申请号：EP06253374.0

申请日：2006-06-28

申请人： LifeScan, Inc.

发明人： Ghabrial, Ragae ,  Fung, Ramie ,  Rezania, Alireza ,  Davis, Janet

IPC分类号： A61L27/38 ,  A61L27/54

CPC分类号： A61L27/38 ,  A61K35/44 ,  A61K38/1866 ,  A61L27/40 ,  A61L27/54 ,  A61L2300/252 ,  A61L2300/414 ,  A61L2300/426 ,  A61L2300/43 ,  A61K2300/00

摘要： This invention provides devices designed to effectively deliver multiple biological entities in combination for tissue engineering. In particular, the present invention provides devices capable of delivering cells or clusters of cells, such as islets of Langerhans, in combination with a therapeutic compound, such as an angiogenic growth factor, for the purpose of transplantation. The devices of the present invention are composed of at least two compartments that are designed independently and processed separately in order to accommodate different requirements of the biological entities. The compartments of the present device can be combined prior to or at the time of implantation, such that the therapeutic released from one compartment provides some benefit to cells hosted by another compartment to promote or improve their proliferation, differentiation, survival, or functionality.

摘要翻译： 本发明提供设计成有效地将多个生物实体组合用于组织工程的装置。 特别地，本发明提供了能够将诸如胰岛的细胞或簇的细胞与治疗化合物如血管生成生长因子结合用于移植目的的装置。 本发明的装置由独立设计和分开设计的至少两个隔室组成，以适应生物实体的不同要求。 本装置的隔室可以在植入之前或在植入时组合，使得从一个隔室释放的治疗剂为由另一隔室托管的细胞提供一些益处以促进或改善其增殖，分化，存活或功能。

公开(公告)号：EP1949916B1

公开(公告)日：2011-08-10

申请号：EP06254532.2

申请日：2006-08-31

申请人： LifeScan, Inc.

发明人： Davis, Janet E. ,  Fung, Ramie

IPC分类号： A61K48/00

CPC分类号： C12N5/0676 ,  C12N5/0678 ,  C12N2501/999

公开(公告)号：EP1949916A1

公开(公告)日：2008-07-30

申请号：EP06254532.2

申请日：2006-08-31

申请人： LifeScan, Inc.

发明人： Davis, Janet E. ,  Fung, Ramie

IPC分类号： A61K48/00

CPC分类号： C12N5/0676 ,  C12N5/0678 ,  C12N2501/999

摘要： This invention relates to a method for inducing the differentiation of cells. In particular, this invention relates to methods that induce cells to differentiate into a pancreatic lineage, or into a pancreatic hormone-producing cell, or into a b-cell lineage. This invention also provides methods and compositions for utilizing such cells in the therapeutic treatment of diabetes.

摘要翻译： 本发明涉及诱导细胞分化的方法。 特别地，本发明涉及诱导细胞分化成胰腺谱系，或产生胰腺激素的细胞或b细胞谱系的方法。 本发明还提供了在治疗糖尿病中利用这种细胞的方法和组合物。

公开(公告)号：EP1743663A3

公开(公告)日：2007-09-19

申请号：EP06253374.0

申请日：2006-06-28

申请人： LifeScan, Inc.

发明人： Ghabrial, Ragae ,  Fung, Ramie ,  Rezania, Alireza ,  Davis, Janet

IPC分类号： A61L27/38 ,  A61L27/54

CPC分类号： A61L27/38 ,  A61K35/44 ,  A61K38/1866 ,  A61L27/40 ,  A61L27/54 ,  A61L2300/252 ,  A61L2300/414 ,  A61L2300/426 ,  A61L2300/43 ,  A61K2300/00

摘要： This invention provides devices designed to effectively deliver multiple biological entities in combination for tissue engineering. In particular, the present invention provides devices capable of delivering cells or clusters of cells, such as islets of Langerhans, in combination with a therapeutic compound, such as an angiogenic growth factor, for the purpose of transplantation. The devices of the present invention are composed of at least two compartments that are designed independently and processed separately in order to accommodate different requirements of the biological entities. The compartments of the present device can be combined prior to or at the time of implantation, such that the therapeutic released from one compartment provides some benefit to cells hosted by another compartment to promote or improve their proliferation, differentiation, survival, or functionality.

公开(公告)号：EP1738760A1

公开(公告)日：2007-01-03

申请号：EP06253370.8

申请日：2006-06-28

申请人： LifeScan, Inc.

发明人： Fung, Ramie

IPC分类号： A61K31/77 ,  A61P29/00

CPC分类号： A61K31/77

摘要： The present invention relates to the use of bioabsorbable and biocompatible amphiphilic polymers as an anti-inflammatory agent. In particular, the present invention provides methods of treating inflammatory diseases or conditions by employing an amphiphilic polymer made of a polybasic acid or a derivative thereof, a monoglyceride and a polyether.

摘要翻译： 本发明涉及生物可吸收和生物相容性两亲性聚合物作为抗炎剂的用途。 特别地，本发明提供了通过使用由多元酸或其衍生物，单酸甘油酯和聚醚制成的两亲性聚合物来治疗炎性疾病或病症的方法。