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1.发明授权
公开(公告)号：EP0954337B1
公开(公告)日：2002-11-20
申请号：EP97931953.0
申请日：1997-07-16
CPC分类号： A61K9/4858 , A61K9/0031 , A61K9/4891 , A61K9/5026 , A61K31/4166 , A61K31/46 , A61K31/465 , A61K31/485 , A61K31/515 , A61K31/522 , A61K31/55 , A61K38/13 , A61K47/58 , A61K47/585 , Y10S514/813 , Y10S514/879
摘要： Nicotine is absorbed systemically from the intestine in therapeutic amounts for the treatment of nicotine responsive conditions, particularly inflammatory skin conditions, Alzheimer's disease, schizophrenia, Parkinson's disease, Tourette's syndrome, depression and to assist in the cessation of smoking. The nicotine is ideally delivered for absorption from the colon as a nicotine-polyacrylate complex in a sustained and delayed released enteric coated capsule. In this way, the high peak plasma levels, which normally give rise to side-effects associated with nicotine are reduced.
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公开(公告)号：EP0893998B2
公开(公告)日：2007-12-12
申请号：EP97904516.8
申请日：1997-02-07
IPC分类号： A61K31/465 , A61P1/00
CPC分类号： A61K31/465 , A61K9/0031
摘要： A method is provided to treat inflammatory bowel disease by locally administering to the colon an effective amount of nicotine or a pharamaceutically acceptable salt thereof, preferably via formulations adapted for delayed oral release or rectal administration. Further provided is a novel formulation for the oral administration of nicotine comprising a polyacrylic polymer complexed with nicotine.
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3.发明公开
公开(公告)号：EP0954337A1
公开(公告)日：1999-11-10
申请号：EP97931953.0
申请日：1997-07-16
CPC分类号： A61K9/4858 , A61K9/0031 , A61K9/4891 , A61K9/5026 , A61K31/4166 , A61K31/46 , A61K31/465 , A61K31/485 , A61K31/515 , A61K31/522 , A61K31/55 , A61K38/13 , A61K47/58 , A61K47/585 , Y10S514/813 , Y10S514/879
摘要： Nicotine is absorbed systemically from the intestine in therapeutic amounts for the treatment of nicotine responsive conditions, particularly inflammatory skin conditions, Alzheimer's disease, schizophrenia, Parkinson's disease, Tourette's syndrome, depression and to assist in the cessation of smoking. The nicotine is ideally delivered for absorption from the colon as a nicotine-polyacrylate complex in a sustained and delayed released enteric coated capsule. In this way, the high peak plasma levels, which normally give rise to side-effects associated with nicotine are reduced.
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公开(公告)号：EP0893998B1
公开(公告)日：2003-04-16
申请号：EP97904516.8
申请日：1997-02-07
IPC分类号： A61K31/465 , A61P1/00
CPC分类号： A61K31/465 , A61K9/0031
摘要： A method is provided to treat inflammatory bowel disease by locally administering to the colon an effective amount of nicotine or a pharamaceutically acceptable salt thereof, preferably via formulations adapted for delayed oral release or rectal administration. Further provided is a novel formulation for the oral administration of nicotine comprising a polyacrylic polymer complexed with nicotine.
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公开(公告)号：EP0893998A1
公开(公告)日：1999-02-03
申请号：EP97904516.0
申请日：1997-02-07
CPC分类号： A61K31/465 , A61K9/0031
摘要： A method is provided to treat inflammatory bowel disease by locally administering to the colon an effective amount of nicotine or a pharamaceutically acceptable salt thereof, preferably via formulations adapted for delayed oral release or rectal administration. Further provided is a novel formulation for the oral administration of nicotine comprising a polyacrylic polymer complexed with nicotine.
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