公开(公告)号：EP1631590A2

公开(公告)日：2006-03-08

申请号：EP04750579.7

申请日：2004-04-23

申请人： MEDAREX, INC.

发明人： CARDARELLI, Josephine, M. ,  CHEN, Tseng-hui, Timothy ,  KING, David ,  BEBBINGTON, Christopher, R. ,  POGUE, Sarah, Lee ,  CARR, Francis J. ,  WILLIAMS, Stephen

IPC分类号： C07K16/00

CPC分类号： C07K16/2866 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/70 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

摘要： Humanized monoclonal antibodies which bind to IFNAR-1, and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the humanized antibodies and therapeutic and diagnostic methods for using the humanized antibodies.

公开(公告)号：EP1631590B1

公开(公告)日：2011-07-27

申请号：EP04750579.7

申请日：2004-04-23

申请人： Medarex, Inc.

发明人： CARDARELLI, Josephine, M. ,  CHEN, Tseng-hui, Timothy ,  KING, David ,  BEBBINGTON, Christopher, R. ,  POGUE, Sarah, Lee ,  CARR, Francis J. ,  WILLIAMS, Stephen

IPC分类号： C07K16/00

CPC分类号： C07K16/2866 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/70 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

摘要： Humanized monoclonal antibodies which bind to IFNAR-1, and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the humanized antibodies and therapeutic and diagnostic methods for using the humanized antibodies.

摘要翻译： 公开了结合IFNAR-1的人源化单克隆抗体以及相关的基于抗体的组合物和分子。 还公开了包含人源化抗体和使用人源化抗体的治疗和诊断方法的药物组合物。