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1.发明公开COMPOSITIONS AND METHODS FOR THE THERAPY OF INFLAMMATORY BOWEL DISEASE 有权ZUSAMMENSETZUNGEN UND VERFAHREN ZUR BEHANDLUNG VONENTZÜNDLICHERDARMERKRANKUNG
公开(公告)号：EP1631312A2
公开(公告)日：2006-03-08
申请号：EP04750581.3
申请日：2004-04-23
申请人： MEDAREX, INC.
IPC分类号： A61K39/395
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/24 , C07K2319/30
摘要： Compositions and methods for the therapy of Inflammatory Bowel Disease (IBD), including Celiac Disease, Crohn’s Disease, and Ulcerative Colitis, are disclosed. Illustrative compositions comprise one or more anti-type 1 interferon antagonists, such as anti-type 1 interferon receptor antibody antagonists and fragments thereof, as well as polypeptides and small molecules that inhibit the interaction of type 1 interferon with its receptor (IFNAR).
摘要翻译： 公开了用于治疗炎症性肠病（IBD）的组合物和方法，包括腹腔疾病，克罗恩病和溃疡性结肠炎。 示例性组合物包含一种或多种抗1型干扰素拮抗剂，例如抗1型干扰素受体抗体拮抗剂及其片段，以及抑制1型干扰素与其受体（IFNAR）相互作用的多肽和小分子。
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公开(公告)号：EP1404356B1
公开(公告)日：2011-04-06
申请号：EP02746852.9
申请日：2002-06-11
申请人： Medarex, Inc.
发明人： BEBBINGTON, Christopher, R. , NIEDER, Matthew, H. , CARDARELLI, Pina, M. , GANGWAR, Sanjeev , PICKFORD, Lesley, B. , PAN, Chin
CPC分类号： G01N33/57492 , A61K47/65 , C12Q1/37 , G01N2333/70596 , G01N2500/00
摘要： The compounds of the invention are modified forms of therapeutic agents. A typical prodrug compound of the invention comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the CD10 enzyme. Methods of treatment using the prodrug and methods of designing a prodrug are also disclosed.
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公开(公告)号：EP1631590A2
公开(公告)日：2006-03-08
申请号：EP04750579.7
申请日：2004-04-23
申请人： MEDAREX, INC.
发明人： CARDARELLI, Josephine, M. , CHEN, Tseng-hui, Timothy , KING, David , BEBBINGTON, Christopher, R. , POGUE, Sarah, Lee , CARR, Francis J. , WILLIAMS, Stephen
IPC分类号： C07K16/00
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/70 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： Humanized monoclonal antibodies which bind to IFNAR-1, and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the humanized antibodies and therapeutic and diagnostic methods for using the humanized antibodies.
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4.发明授权
公开(公告)号：EP1631590B1
公开(公告)日：2011-07-27
申请号：EP04750579.7
申请日：2004-04-23
申请人： Medarex, Inc.
发明人： CARDARELLI, Josephine, M. , CHEN, Tseng-hui, Timothy , KING, David , BEBBINGTON, Christopher, R. , POGUE, Sarah, Lee , CARR, Francis J. , WILLIAMS, Stephen
IPC分类号： C07K16/00
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/70 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： Humanized monoclonal antibodies which bind to IFNAR-1, and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the humanized antibodies and therapeutic and diagnostic methods for using the humanized antibodies.
摘要翻译： 公开了结合IFNAR-1的人源化单克隆抗体以及相关的基于抗体的组合物和分子。 还公开了包含人源化抗体和使用人源化抗体的治疗和诊断方法的药物组合物。
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公开(公告)号：EP1631312B1
公开(公告)日：2008-09-10
申请号：EP04750581.3
申请日：2004-04-23
申请人： MEDAREX, INC.
IPC分类号： A61K39/395
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/24 , C07K2319/30
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公开(公告)号：EP1404356A2
公开(公告)日：2004-04-07
申请号：EP02746852.9
申请日：2002-06-11
申请人： Medarex, Inc.
发明人： BEBBINGTON, Christopher, R. , NIEDER, Matthew, H. , CARDARELLI, Pina, M. , GANGWAR, Sanjeev , PICKFORD, Lesley, B. , PAN, Chin
CPC分类号： G01N33/57492 , A61K47/65 , C12Q1/37 , G01N2333/70596 , G01N2500/00
摘要： The compounds of the invention are modified forms of therapeutic agents. A typical prodrug compound of the invention comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the CD10 enzyme. Methods of treatment using the prodrug and methods of designing a prodrug are also disclosed.
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