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公开(公告)号：EP3498694A1
公开(公告)日：2019-06-19
申请号：EP17382845.0
申请日：2017-12-12
申请人： MEDIBIOFARMA, S.L.
IPC分类号： C07D213/75 , C07C255/50 , C07D401/04 , C07D237/20 , C07C237/20 , C07D295/192 , A61P35/00 , A61K31/185 , A61K31/444 , A61K31/44 , A61K31/50
摘要： The present invention relates to novel benzamides derivatives of formula (I)
as modulators of PPAR-gamma receptor, to processes for their preparation, to pharmaceutical compositions comprising said compounds and to said compound for use in the treatment of pathological conditions, disorders or diseases that can improve by modulation of PPAR-gamma receptor, such as cancer; metabolic diseases, inflammatory diseases, respiratory disorders, autoimmune diseases, neurodegenerative diseases, cardiovascular diseases and renal diseases.-
2.发明公开
公开(公告)号：EP3921310A1
公开(公告)日：2021-12-15
申请号：EP20704272.2
申请日：2020-02-07
申请人： MEDIBIOFARMA, S.L.
发明人： PALOMINO LARIA, Julio Castro , CAMACHO GÓMEZ, Juan , RODRÍGUEZ IGLESIAS, Rodolfo , VELILLA MARTÍNEZ, Irene
IPC分类号： C07D231/12 , C07D333/24 , C07C233/53 , C07D213/56 , C07D213/61 , A61P35/00 , A61K31/166 , A61K31/4409
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3.发明公开
公开(公告)号：EP3693359A1
公开(公告)日：2020-08-12
申请号：EP19382088.3
申请日：2019-02-08
申请人： MEDIBIOFARMA, S.L.
发明人： PALOMINO LARIA, Julio Castro , CAMACHO GÓMEZ, Juan , RODRÍGUEZ IGLESIAS, Rodolfo , VELILLA MARTÍNEZ, Irene
IPC分类号： C07D231/12 , C07D333/24 , C07C233/53 , C07D213/56 , C07D213/61 , A61P35/00 , A61K31/166 , A61K31/4409
摘要： The present invention relates to novel, optionally substituted, N-benzyl-2-phenoxybenzamide derivatives of formula (I)
as modulators of EP4 and/or EP2 receptors of prostaglandin E2 (PGE2), to processes for their preparation, to pharmaceutical compositions comprising said compounds and to said compound for use in the treatment of pathological conditions, disorders or diseases that can improve by modulation of EP4 and/or EP2 receptors of prostaglandin E2 (PGE2) such as cancer disease, pain, inflammation, neurodegenerative diseases and kidney diseases.
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