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1.发明公开
公开(公告)号：EP3693359A1
公开(公告)日：2020-08-12
申请号：EP19382088.3
申请日：2019-02-08
申请人： MEDIBIOFARMA, S.L.
发明人： PALOMINO LARIA, Julio Castro , CAMACHO GÓMEZ, Juan , RODRÍGUEZ IGLESIAS, Rodolfo , VELILLA MARTÍNEZ, Irene
IPC分类号： C07D231/12 , C07D333/24 , C07C233/53 , C07D213/56 , C07D213/61 , A61P35/00 , A61K31/166 , A61K31/4409
摘要： The present invention relates to novel, optionally substituted, N-benzyl-2-phenoxybenzamide derivatives of formula (I)
as modulators of EP4 and/or EP2 receptors of prostaglandin E2 (PGE2), to processes for their preparation, to pharmaceutical compositions comprising said compounds and to said compound for use in the treatment of pathological conditions, disorders or diseases that can improve by modulation of EP4 and/or EP2 receptors of prostaglandin E2 (PGE2) such as cancer disease, pain, inflammation, neurodegenerative diseases and kidney diseases.-
2.发明公开HIGH SELECTIVE HERBICIDAL PHENOXYPROPIONIC ACID ALKOXYCARBONYL ANILID COMPOUNDS AND METHOD OF PREPARING THEREOF 有权高选择性除草剂苯氧ALKOXYCARBONYLANILIDE及其制造方法
公开(公告)号：EP1206187A2
公开(公告)日：2002-05-22
申请号：EP00948384.3
申请日：2000-07-31
发明人： Kim, Dae Whang , Chang, Hae Sung , Ko, Young Kwan , Ryu, Jae Wook , Woo, Jae Chun , Koo, Dong Wan , Kim, Tae-Joon
IPC分类号： A01N43/76 , C07D263/58 , C07C235/24 , C07C235/16 , C07C233/53
CPC分类号： C07D263/58 , A01N43/76 , C07C233/54 , C07C235/24
摘要： The present invention relates to high selective herbicidal phenoxypropionic acid alkoxycarbonyl anilid compounds, method of preparing thereof, their use to control barnyard grass produced from rice, and a composition as suitable herbicides.
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公开(公告)号：EP0259778A1
公开(公告)日：1988-03-16
申请号：EP87112849.2
申请日：1987-09-03
发明人： Zeeck, Axel Prof.-Dr. , Breiding-Mack, Sabine Dr. , Grabley, Susanne Dr. , Voelskow, Hartmut Dr. , Seibert, Gerhard Prof.-Dr.
IPC分类号： C07C233/53 , C12P7/40 , C12P13/00 , C12P1/06 , C12N1/20 , A61K31/185
CPC分类号： C12P13/02
摘要： Es wurde die 2-Acetylamino-gentisinsäure nach Kultivierung eines Bakterium der Gattung Streptomyces aus der Kulturbrühe isoliert. Diese Verbindung zeigt antibakterielle Wirkung gegen gram-positive und gram-negative Bakterien.
摘要翻译： 培养链霉菌属细菌后，从培养液中分离2-乙酰氨基 - 龙胆酸。 该化合物对革兰氏阳性菌和革兰氏阴性菌显示出抗菌活性。
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4.发明授权
公开(公告)号：EP2448913B1
公开(公告)日：2013-04-24
申请号：EP10724308.1
申请日：2010-06-09
IPC分类号： C07C231/02 , C07C233/47 , C07C233/53 , C07C303/22 , C07C309/14 , B01J19/12 , H05B6/70 , H05B6/80
CPC分类号： C07C231/02 , B01J19/126 , B01J2219/00033 , B01J2219/0888 , B01J2219/0892 , B01J2219/1227 , C07C303/22 , H05B6/701 , H05B6/806 , C07C233/47 , C07C233/54 , C07C309/14 , C07C309/15
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5.发明授权HIGH SELECTIVE HERBICIDAL PHENOXYPROPIONIC ACID ALKOXYCARBONYL ANILID COMPOUNDS AND METHOD OF PREPARING THEREOF 有权高选择性除草剂苯氧ALKOXYCARBONYLANILIDE及其制造方法
公开(公告)号：EP1206187B1
公开(公告)日：2003-10-01
申请号：EP00948384.3
申请日：2000-07-31
发明人： Kim, Dae Whang , Chang, Hae Sung , Ko, Young Kwan , Ryu, Jae Wook , Woo, Jae Chun , Koo, Dong Wan , Kim, Tae-Joon
IPC分类号： A01N43/76 , C07D263/58 , C07C235/24 , C07C235/16 , C07C233/53
CPC分类号： C07D263/58 , A01N43/76 , C07C233/54 , C07C235/24
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6.发明公开X-ray contrast media for prolonged opacification 失效RöntgenkontrastmittelfürverlängerteOpacifikation。
公开(公告)号：EP0436316A1
公开(公告)日：1991-07-10
申请号：EP90313363.5
申请日：1990-12-07
申请人： Sovak, Milos
发明人： Sovak, Milos
IPC分类号： C07C233/53 , C07C235/16 , C07C237/46 , A61K49/04
CPC分类号： C07C237/46 , A61K49/0433 , C07C233/54 , C07C233/55
摘要： Hydroxyalkyl amino-substituted triiodobenzoates are provided, where the remaining position is substituted by amino or carboxy. The compounds have low solubility in the gastrointestinal tract, but are resorbable from extravisceral body cavities. They can be readily formulated and used as contract media for the plain radiography of the GI tract.
Also, addition polymers comprised of triiodo compounds bonded through an amino nitrogen to a non-oxo-carbonyl group of an addition polymerizable monomer are provided. The polymers are highly water soluble physiologically acceptable, and not resorbable from the GI tract, but from the extravisceral body cavities. The polymers find use for computer tomography of the GI tract.摘要翻译： 提供羟基烷基氨基取代的三碘苯甲酸酯，其中剩余的位置被氨基或羧基取代。 这些化合物在胃肠道中溶解度低，但可从外部体腔吸收。 它们可以容易地制成并用作胃肠道平片摄影术的合同介质。 此外，提供了由通过氨基氮键合到可加成聚合单体的非羰基羰基上的三碘化合物组成的加成聚合物。 聚合物是高度水溶性的生理上可接受的，并且不能从胃肠道吸收，而是从外部体腔吸收。 聚合物用于胃肠道的计算机断层扫描。
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7.发明公开
公开(公告)号：EP3921310A1
公开(公告)日：2021-12-15
申请号：EP20704272.2
申请日：2020-02-07
申请人： MEDIBIOFARMA, S.L.
发明人： PALOMINO LARIA, Julio Castro , CAMACHO GÓMEZ, Juan , RODRÍGUEZ IGLESIAS, Rodolfo , VELILLA MARTÍNEZ, Irene
IPC分类号： C07D231/12 , C07D333/24 , C07C233/53 , C07D213/56 , C07D213/61 , A61P35/00 , A61K31/166 , A61K31/4409
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8.发明公开
公开(公告)号：EP2448913A2
公开(公告)日：2012-05-09
申请号：EP10724308.1
申请日：2010-06-09
IPC分类号： C07C231/02 , C07C233/47 , C07C233/53 , C07C303/22 , C07C309/14
CPC分类号： C07C231/02 , B01J19/126 , B01J2219/00033 , B01J2219/0888 , B01J2219/0892 , B01J2219/1227 , C07C303/22 , H05B6/701 , H05B6/806 , C07C233/47 , C07C233/54 , C07C309/14 , C07C309/15
摘要： The invention relates to a continuous method for N-acylating amino group-carrying organic acids by reacting at least one carboxylic acid of formula (I) R
1 -COOH (I), wherein R
1 represents hydrogen or an optionally substituted hydrocarbon group with 1 to 50 carbon atoms, with at least one at least one amino group-carrying organic acid of formula (II) R
2 NH-A-X (II), wherein A represents an optionally substituted hydrocarbon group with 1 to 50 carbon atoms, X represents an acid group or the metal salt thereof and R
2 represents hydrogen, an optionally substituted hydrocarbon group with 1 to 50 C atoms or a group of the formula –A-X, wherein A and X independently are defined as above, in a reaction tube the longitudinal axis of which extends in the direction of propagation of the microwaves of a monomode microwave applicator, under microwave irradiation to form amide.-
9.发明公开PHENYL-PRENYL DERIVATIVES, OF MARINE AND SYNTHETIC ORIGIN, FOR THE TREATMENT OF COGNITIVE, NEURODEGENERATIVE OR NEURONAL DISEASES OR DISORDERS 审中-公开PHENYLPRENYLDERIVATE海洋和合成认知，神经变性疾病或神经元疾病或治疗的 疾病
公开(公告)号：EP2254855A1
公开(公告)日：2010-12-01
申请号：EP09709262.1
申请日：2009-02-06
申请人： NOSCIRA, S.A.
发明人： LÓPEZ OGALLA, Javier , MUÑOZ RUIZ, Pilar , ALONSO GORDILLO, Diana , MEDINA PADILLA, Miguel , GARCIA PALOMERO, Esther , MARTINEZ GIL, Ana , CASTRO MORERA, Ana
IPC分类号： C07C43/20 , C07C47/228 , C07C69/614 , C07C69/708 , C07C233/53
CPC分类号： C07C69/92 , C07C47/565 , C07C47/575 , C07C65/19 , C07C65/28 , C07C69/86 , C07C69/90 , C07C235/46
摘要： The present invention is related to a family of phenyl-prenyl derivatives of formula (I), and to their use in the treatment of cognitive, neurodegenerative or neuronal diseases or disorders, such as Alzheimer's disease or Parkinson's Disease. The present invention also relates to pharmaceutical compositions comprising the same. Further, the present invention is directed to the compounds of formula (I) for medical use, particularly for the use for the treatment and/or prevention of a cognitive, neurodegenerative or neuronal disease or disorder, and to the use of the compounds in the manufacture of a medicament for the treatment and/or prevention of a cognitive, neurodegenerative or neuronal disease or disorder.
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公开(公告)号：EP1726580A4
公开(公告)日：2008-02-13
申请号：EP05721059
申请日：2005-03-14
发明人： YASUMA TSUNEO , NEGORO NOBUYUKI , SASAKI SHINOBU
IPC分类号： C07C229/42 , A61K31/16 , A61K31/195 , A61K31/222 , A61K31/337 , A61K31/343 , A61K31/382 , A61K31/40 , A61K31/4015 , A61K31/404 , A61K31/4152 , A61K31/42 , A61K31/426 , A61K31/427 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/47 , A61K31/5375 , A61P3/10 , A61P43/00 , C07C233/18 , C07C233/53 , C07C235/06 , C07C259/06 , C07C309/66 , C07C311/21 , C07C311/51 , C07C317/18 , C07C317/32 , C07C323/12 , C07D207/27 , C07D207/404 , C07D209/08 , C07D209/14 , C07D211/46 , C07D213/64 , C07D213/69 , C07D213/74 , C07D213/76 , C07D215/06 , C07D215/12 , C07D231/12 , C07D231/22 , C07D231/24 , C07D261/08 , C07D277/28 , C07D295/18 , C07D305/06 , C07D307/79 , C07D335/02 , C07D401/12 , C07D409/12 , C07D417/12 , C07F7/18 , C07F9/40
CPC分类号： C07C311/21 , C07C229/42 , C07C309/66 , C07C311/51 , C07C317/18 , C07C317/32 , C07C323/12 , C07C2601/02 , C07C2602/08 , C07D213/74 , C07D215/06 , C07D231/24 , C07D277/28 , C07D307/79 , C07D409/12 , C07D417/12 , C07F9/4006
摘要： A compound represented by the formula (1) (wherein the symbols are the same as defined in the description), a salt thereof, and a prodrug thereof. They unexpectedly have excellent GPR40 receptor agonistic activity and are excellent in properties required of medicines, such as stability. They can be a medicine which is safe and useful as a preventive/therapeutic agent for pathological states or diseases in which a GPR40 receptor participates, such as diabetes.
摘要翻译： 由式（1）（其中符号与说明书中定义的相同）代表的化合物，其盐及其前药。 它们意外地具有优异的GPR40受体激动剂活性，并且在稳定性等药物所需的性能方面优异。 它们可以是安全有用的药物，作为GPR40受体参与的病理状态或疾病（例如糖尿病）的预防/治疗剂。
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