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公开(公告)号：EP0914179B1
公开(公告)日：2004-09-22
申请号：EP97930223.9
申请日：1997-06-25
申请人： Medtronic, Inc.
CPC分类号： A61N1/3601 , A61N1/3704
摘要： A gain control method for providing a gain controlled signal representative of a periodic physiological parameter of a patient includes providing a signal characteristic of the periodic physiological parameter. The periodic physiological parameter includes a plurality of periodic cycles. Gain of the signal is updated only once per periodic cycle following detection of a periodic event. The updating is performed by monitoring an amplitude of the signal between detection of periodic events and comparing the amplitude to a gain control amplitude threshold. Gain of the signal is updated as a function of the comparison. Further, gain is updated following expiration of a predetermined period of time if a periodic event is not detected within the predetermined period of time. The physiological parameter may be respiratory effort. An apparatus for providing such gain control is also provided.
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公开(公告)号：EP0917485A1
公开(公告)日：1999-05-26
申请号：EP97932309.0
申请日：1997-06-26
申请人： MEDTRONIC, INC.
CPC分类号： A61B5/03 , A61B5/7207 , A61N1/3601
摘要： An implantable sensing device includes a sensing element and a mounting element. The mounting element has a first end and a second end with a longitudinal axis therethrough. The sensing element is positioned at the first end of the mounting element with the mounting element having a length that is adjustable along the longitudinal axis. The mounting element includes a sleeve having a first open end and a second open end with the longitudinal axis therethrough. The sensing element is positioned in the second open end and includes a lead body connected thereto extending through the second open end. The sleeve includes an outer sleeve member coupled for adjustment along the longitudinal axis with respect to an inner sleeve member. Further, the mounting element may include a flexible element about the first open end extending outwardly relative to the longitudinal axis and a flange element extending outwardly relative to the longitudinal axis from at least a portion of the second end. The device can be implanted in a bone with the flange element and the flexible element for direct or indirect contact with the anterior and posterior surface of the bone.
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公开(公告)号：EP0914179A1
公开(公告)日：1999-05-12
申请号：EP97930223.0
申请日：1997-06-25
申请人： MEDTRONIC, INC.
CPC分类号： A61N1/3601 , A61N1/3704
摘要： A gain control method for providing a gain controlled signal representative of a periodic physiological parameter of a patient includes providing a signal characteristic of the periodic physiological parameter. The periodic physiological parameter includes a plurality of periodic cycles. Gain of the signal is updated only once per periodic cycle following detection of a periodic event. The updating is performed by monitoring an amplitude of the signal between detection of periodic events and comparing the amplitude to a gain control amplitude threshold. Gain of the signal is updated as a function of the comparison. Further, gain is updated following expiration of a predetermined period of time if a periodic event is not detected within the predetermined period of time. The physiological parameter may be respiratory effort. An apparatus for providing such gain control is also provided.
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公开(公告)号：EP0917486A1
公开(公告)日：1999-05-26
申请号：EP97933273.0
申请日：1997-06-25
申请人： MEDTRONIC, INC.
CPC分类号： A61N1/37211 , A61N1/08 , A61N1/3601 , A61N1/37247
摘要： A testing method for use with a patient stimulation system includes providing a stimulation system including a patient control unit. The patient control unit initiates and terminates treatment periods. At least one period of stimulation to stimulate the patient is automatically provided upon initiating a treatment period. Another method includes a system test method for use with a therapy system. The method includes providing a therapy system having a plurality of components; the therapy system physiologically interacting with a patient. A diagnostic self test of a component of the therapy system is performed internally to the system to determine if the component is functioning properly at a time when the therapy system is not interacting physiologically with the patient. Apparatus for using such methods are also provided.
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公开(公告)号：EP0907926A1
公开(公告)日：1999-04-14
申请号：EP97932310.0
申请日：1997-06-26
申请人： MEDTRONIC, INC.
CPC分类号： A61B5/03 , A61B5/07 , A61B5/113 , A61N1/3601
摘要： A method of predicting critical points in patient respiration includes monitoring at least one characteristic of a respiratory effort waveform of a patient to detect a respiratory event. A refractory period is defined that includes a hard refractory period during which time the respiratory event cannot be responded to and a soft refractory period following the hard refractory period. The respiratory event outside of the refractory period is detected as a function of a first set of predetermined parameters for the monitored at least one characteristic and the respiratory event within the soft refractory period is detected as a function of a second set of predetermined parameters for the monitored at least one characteristic. The respiratory event may be inspiration onset and the characteristic of the respiratory effort waveform monitored is at least one of slope and amplitude. The refractory period may be defined based on detection of inspiration offset and further may be defined based on inspiration offset, an average respiratory period, and an average time of inspiration. Further, stimulation may be provided in response to a detected inspiration onset. Another method of predicting critical points includes sampling the amplitude of the respiratory effort waveform of a patient. A sample signal is generated representative of at least one characteristic of the respiratory effort waveform based on each amplitude sample. The sample signals representative of the at least one characteristic of the respiratory effort waveform are monitored and a respiratory event is detected as a function of at least two sample signals. Apparatus and systems for use with such methods are also described.
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6.发明公开CARDIAC ASSIST DEVICE HAVING CIRCADIAN SKELETAL MUSCLE STIMULATION 失效与昼夜骨骼肌收缩刺激HERZUNTERSTÜZUNGSVORRICHTUNG
公开(公告)号：EP0850087A1
公开(公告)日：1998-07-01
申请号：EP96927400.0
申请日：1996-08-12
申请人： MEDTRONIC, INC.
IPC分类号： A61N1
CPC分类号： A61N1/36042 , A61N1/36585 , A61N1/3962
摘要： A cardiac assist device having circadian muscle stimulation. In particular the present invention operates in one of two states, either day mode or night mode. During the day mode, muscle stimulation and conditioning are performed according to a first schedule. During the night mode, muscle stimulation and conditioning are performed according to a second schedule. In addition, the night mode is only reached if the night mode is permitted, a set number of sensed beats are less than the night mode rate, and the time of day is nighttime. The night mode is interrupted if the night mode is turned off, the time of day is daytime, or a set number of beats are greater than the night rate. In short, the present invention provides for skeletal muscle stimulation at a less fatiguing level during the night than during the day.
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公开(公告)号：EP0957983B1
公开(公告)日：2002-05-02
申请号：EP97931392.1
申请日：1997-06-25
申请人： MEDTRONIC, INC.
IPC分类号： A61N1/36
CPC分类号： A61N1/3601
摘要： A method for operating an implantable therapy system to conserve energy includes providing an implantable sensing device that generates a signal as a function of a physiological parameter of a patient during a treatment period. The signal is monitored during at least portions of the treatment period to detect a physiological event for use in controlling therapy of the patient during the treatment period. Energy consumption by the sensing device is terminated during the treatment period for at least portions of the treatment period when signal monitoring is not performed. Another method for operating an implantable therapy system for conserving energy includes providing an implantable component for performance of a function during a treatment period for the therapy system. The implantable component is operable in at least a first state during the treatment period and a second state outside of the treatment period; the first state using more energy than the second state. The implantable component is operated in the first state when performance of the function during a treatment period is required and operated in the second state when performance of the function is not required outside the treatment period. Another method of operating an implantable therapy system includes monitoring a periodic physiological parameter for controlling therapy of a patient during a treatment period. The measured physiological period for the parameter of the patient is compared to at least one predetermined period threshold to determine nonperiodic behavior of the monitored periodic physiological parameter and suspending therapy of the patient as a function thereof. Systems for use with such methods are also provided.
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公开(公告)号：EP0959831A1
公开(公告)日：1999-12-01
申请号：EP97916249.0
申请日：1997-03-25
申请人： MEDTRONIC, INC.
CPC分类号： A61N1/36046 , A61F9/00718 , A61N1/05
摘要： The implantable eyelid electrode apparatus includes a body of nonconductive material having first and second edges and first and second ends. A longitudinal axis extends between the first and second ends and a distance from the longitudinal axis to at least one of the first and second edges decreases towards at least one of the first and second ends. Conductive material is positioned at a surface of the body and at least one lead wire is in electrical contact with the conductive material. Further, the conductive material may include a number of conductive electrodes which are capable of being connected as an anode, a cathode, or left in an open configuration. The conductive electrodes may be strip electrodes positioned perpendicular to the longitudinal axis, and further, the plurality of conductive electrodes may be configured in a guarded multipolar configuration. An electrode device may be implanted in the upper eyelid or the lower eyelid or both. Moreover, a method for implanting an electrode apparatus includes positioning the electrode apparatus adjacent the orbicularis oculi muscle fiber such that the conductive material of the implantable eyelid electrode is adjacent the surface of the muscle fibers. The conductive electrodes, which may be of a strip configuration, are positioned with their length perpendicular to the muscle fibers, when implanted, to promote current passing parallel to the muscle fibers.
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公开(公告)号：EP0917485B1
公开(公告)日：2004-09-22
申请号：EP97932309.4
申请日：1997-06-26
申请人： Medtronic, Inc.
CPC分类号： A61B5/03 , A61B5/7207 , A61N1/3601
摘要： An implantable sensing device includes a sensing element and a mounting element. The mounting element has a first end and a second end with a longitudinal axis therethrough. The sensing element is positioned at the first end of the mounting element with the mounting element having a length that is adjustable along the longitudinal axis. The mounting element includes a sleeve having a first open end and a second open end with the longitudinal axis therethrough. The sensing element is positioned in the second open end and includes a lead body connected thereto extending through the second open end. The sleeve includes an outer sleeve member coupled for adjustment along the longitudinal axis with respect to an inner sleeve member. Further, the mounting element may include a flexible element about the first open end extending outwardly relative to the longitudinal axis and a flange element extending outwardly relative to the longitudinal axis from at least a portion of the second end. The device can be implanted in a bone with the flange element and the flexible element for direct or indirect contact with the anterior and posterior surface of the bone.
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公开(公告)号：EP0959831B1
公开(公告)日：2003-06-11
申请号：EP97916249.2
申请日：1997-03-25
申请人： MEDTRONIC, INC.
CPC分类号： A61N1/36046 , A61F9/00718 , A61N1/05
摘要： The implantable eyelid electrode apparatus includes a body of nonconductive material having first and second edges and first and second ends. A longitudinal axis extends between the first and second ends and a distance from the longitudinal axis to at least one of the first and second edges decreases towards at least one of the first and second ends. Conductive material is positioned at a surface of the body and at least one lead wire is in electrical contact with the conductive material. Further, the conductive material may include a number of conductive electrodes which are capable of being connected as an anode, a cathode, or left in an open configuration. The conductive electrodes may be strip electrodes positioned perpendicular to the longitudinal axis, and further, the plurality of conductive electrodes may be configured in a guarded multipolar configuration. An electrode device may be implanted in the upper eyelid or the lower eyelid or both. Moreover, a method for implanting an electrode apparatus includes positioning the electrode apparatus adjacent the orbicularis oculi muscle fiber such that the conductive material of the implantable eyelid electrode is adjacent the surface of the muscle fibers. The conductive electrodes, which may be of a strip configuration, are positioned with their length perpendicular to the muscle fibers, when implanted, to promote current passing parallel to the muscle fibers.
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