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公开(公告)号:EP0940400A4
公开(公告)日:2002-10-02
申请号:EP97909602
申请日:1997-10-22
发明人: AKAHOSHI FUMIHIKO , ASHIMORI ATSUYUKI , YOSHIMURA TAKUYA , EDA MASAHIRO , SAKASHITA HIROSHI , NAKAJIMA MASAHIDE , IMADA TERUAKI
IPC分类号: C07D413/12 , A61K31/435 , A61K38/00 , C07K5/078 , A61K31/505 , C07D239/47 , C07D417/12 , C07D498/04 , C07K5/04
CPC分类号: C07K5/06139 , A61K38/00
摘要: Heterocyclic amide compounds represented by general formula (I) or pharmacologically acceptable salts thereof; medicinal compositions thereof; and medicinal uses of the same wherein each symbol is as defined in the specification. These compounds and pharmacologically acceptable salts thereof have excellent effects of inhibiting chymases on mammals including human being and can be administered orally or parenterally. Thus, they are useful as chymase inhibitors in preventing and treating various diseases caused by chymases typified by those caused by angiotensin II.