公开(公告)号：EP1308439A4

公开(公告)日：2007-02-14

申请号：EP01955660

申请日：2001-08-10

申请人： MITSUBISHI PHARMA CORP

发明人： KITAJIMA HIROSHI ,  SAKASHITA HIROSHI ,  AKAHOSHI FUMIHIKO ,  HAYASHI YOSHIHARU

IPC分类号： A61P1/02 ,  A61P3/04 ,  A61P3/10 ,  A61P13/08 ,  A61P17/00 ,  A61P31/18 ,  A61P35/04 ,  A61P37/06 ,  A61P43/00 ,  C07D207/16 ,  C07D401/14 ,  C07D403/14 ,  C07D413/14 ,  C07D417/06 ,  C07D417/14 ,  C07D471/10 ,  C07D487/04 ,  C07D498/04

CPC分类号： C07D401/14 ,  C07D207/16 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/06 ,  C07D417/14 ,  C07D471/10 ,  C07D487/04

摘要： The invention aims at providing compounds which exhibit therapeutic effects through the inhibition of DPP-IV and are satisfactory as drugs. The invention has been accomplished by finding that η-substituted proline derivatives of the general formula (I) exhibit potent DPP-IV inhibitory activities and improving the same in stability. [In the general formula, each symbol is as defined in the description.]

公开(公告)号：EP1426366A4

公开(公告)日：2004-12-08

申请号：EP02767958

申请日：2002-09-13

申请人： MITSUBISHI PHARMA CORP

发明人： SAKASHITA HIROSHI ,  TOSHIDA TOMOHIRO ,  KITAJIMA HIROSHI ,  TAKEUCHI MASAHIRO ,  TANAKA YOSHIHITO ,  YOSHIMURA TAKUYA ,  AKAHOSHI FUMIHIKO ,  HAYASHI YOSHIHARU

IPC分类号： A61P3/04 ,  A61P3/10 ,  A61P43/00 ,  C07D277/04 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  C07D417/12 ,  C07D417/14

CPC分类号： C07D277/04

摘要： A thiazolidine derivative represented by the general formula (I) [wherein X represents a substituent represented by the formula (I-a) or (I-b) (wherein m is 1 or 2; n is an integer of 1 to 5; X' represents hydrogen, etc.; Y' represents arylamino, heterocycle, etc.; A represents carbon or nitrogen; and Q represents aryl, etc.); Y represents methylene, sulfur, etc.; and Z represents hydrogen or cyano] and a pharmaceutically acceptable salt of the derivative. They have potent DPP-IV inhibitory activity and can hence be provided as, e.g. a preventive/remedy for diabetes or preventive/remedy for obesity.

公开(公告)号：EP0940400A4

公开(公告)日：2002-10-02

申请号：EP97909602

申请日：1997-10-22

申请人： MITSUBISHI PHARMA CORP

发明人： AKAHOSHI FUMIHIKO ,  ASHIMORI ATSUYUKI ,  YOSHIMURA TAKUYA ,  EDA MASAHIRO ,  SAKASHITA HIROSHI ,  NAKAJIMA MASAHIDE ,  IMADA TERUAKI

IPC分类号： C07D413/12 ,  A61K31/435 ,  A61K38/00 ,  C07K5/078 ,  A61K31/505 ,  C07D239/47 ,  C07D417/12 ,  C07D498/04 ,  C07K5/04

CPC分类号： C07K5/06139 ,  A61K38/00

摘要： Heterocyclic amide compounds represented by general formula (I) or pharmacologically acceptable salts thereof; medicinal compositions thereof; and medicinal uses of the same wherein each symbol is as defined in the specification. These compounds and pharmacologically acceptable salts thereof have excellent effects of inhibiting chymases on mammals including human being and can be administered orally or parenterally. Thus, they are useful as chymase inhibitors in preventing and treating various diseases caused by chymases typified by those caused by angiotensin II.