公开(公告)号：EP2393783A1

公开(公告)日：2011-12-14

申请号：EP09760689.1

申请日：2009-11-30

申请人： Mallinckrodt LLC

发明人： WANG, Peter, X. ,  JIANG, Tao ,  LIAO, Subo ,  MOORE, Erin

IPC分类号： C07D221/28 ,  C07D489/02

CPC分类号： C07D489/02 ,  C07D221/28

摘要： The present disclosure generally relates to a process for converting a fused, tricyclic compound to a fused, tetracyclic compound that includes a furan ring therein. More particularly, the present disclosure related to a process for preparing a hydrocodone compound, or a compound structurally related thereto, and in particular (+)-hydrocodone, by subjecting a structurally corresponding sinomeπine starting compound to a super acid-assisted furan ring closure reaction. Formula I, II. Examples of super acids useful in the processes described herein include, but are not limited to, trifluoromethanesulfonic acid (CF
3 SO
3 H), tetrafluoroboric acid (HBF
4 ), fluorophosphoric acid (HPF
6 ), fluorosulfuric acid (FSO
3 H). and fiuoroantimonic acid (HSbF
8 ), fluorophosphoric acid (FP(O)(OH)
2 ) as well as combinations thereof.

公开(公告)号：EP2393783B1

公开(公告)日：2014-04-30

申请号：EP09760689.1

申请日：2009-11-30

申请人： Mallinckrodt LLC

发明人： WANG, Peter, X. ,  JIANG, Tao ,  LIAO, Subo ,  MOORE, Erin

IPC分类号： C07D221/28 ,  C07D489/02

CPC分类号： C07D489/02 ,  C07D221/28