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142 条记录 (耗时 0.018 秒)

    OPIOID AND OPIOID-LIKE COMPOUNDS AND USES THEREOF
    7.
    发明公开
    OPIOID AND OPIOID-LIKE COMPOUNDS AND USES THEREOF 审中-公开
    OPIOID UNDOPIOIDÄHNLICHEVERBINDUNGEN UND VERWENDUNG DAVON

    公开(公告)号：EP2987788A1

    公开(公告)日：2016-02-24

    申请号：EP15186541.7

    申请日：2003-05-16

    申请人： Taiwanj Pharmaceuticals Co., Ltd.

    发明人： FAN, Chin-Tsai ,  YEN, Mao-Hsiung

    IPC分类号： C07D221/28 ,  A61K31/485 ,  C07D489/10 ,  C07D489/02 ,  C07D221/26

    CPC分类号： A61K31/485

    摘要： The present invention relates to opioid and opioid-like compounds, and pharmaceutical formulations containing the same and methods of use thereof. Uses of the present invention include, but are not limited to, use for the prevention and treatment of septic shock and other disorders. The compounds described herein can be water soluble and can act through mechanisms mediated through pathways other than opiate receptors.

    摘要翻译： 本发明涉及阿片样物质和阿片样物质化合物，以及含有其的药物制剂及其使用方法。 本发明的用途包括但不限于用于预防和治疗败血性休克和其它疾病的用途。 本文所述的化合物可以是水溶性的，并且可以通过除阿片受体之外的途径介导的机制起作用。

    SINOMENINE DERIVATIVES, SYNTHETIC METHODS AND USES THEREOF
    10.
    发明公开
    SINOMENINE DERIVATIVES, SYNTHETIC METHODS AND USES THEREOF 有权
    SINOMENINDERIVATE，合成方法及其用途

    公开(公告)号：EP2535332A4

    公开(公告)日：2013-08-07

    申请号：EP11741906

    申请日：2011-02-09

    申请人： SHANGHAI INST ORGANIC CHEM ,  SHANGHAI INST BIOL SCIENCES

    发明人： YAO ZHUJUN ,  SUN BING ,  LOU YANGTONG ,  YANG ZHENYU ,  CHEN AIZHONG ,  MA ZHAO

    IPC分类号： C07D221/28 ,  A61K31/485 ,  A61P29/00 ,  A61P37/06

    CPC分类号： C07D221/28 ,  A61K31/485

    摘要： The invention relates to sinomenine derivatives, methods for their synthesis and their applications. The sinomenine derivatives include oxidation derivatives, and C-10 substituted sinomenine derivatives. Based on the readily oxidizable phenol group on sinomenine structure, using oxidation, oxidative dearomatization, or conjugated addition aromatization, one can introduce C-10 substitutions to synthesize the sinomenine derivatives. The sinomenine derivatives of the invention have the following structures: Using in vitro TNF-± inhibition assay, the activities of the synthetic compounds are assessed. Results from these assays shown that most compounds have anti-inflammatory effects, and some compounds have better activities than that of sinomenine. These compounds may be used in treating immune diseases such as rheumatoid arthritis (RA).