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公开(公告)号：EP2197906A1
公开(公告)日：2010-06-23
申请号：EP08802876.6
申请日：2008-10-13
发明人： FALK, Kirsten , RÖTZSCHKE, Olaf , LUCIUS, Richard
IPC分类号： C07K14/445 , A61K39/002 , C12N15/62
CPC分类号： C07K14/445 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , C07K2319/40 , Y02A50/401 , Y02A50/412 , Y02A50/414
摘要： The present invention relates to a fusion polypeptide comprising a) at least one fragment of the Plasmodium falciparum S-antigen or a variant thereof, wherein the fragment comprises one or a plurality of Plasmodium falciparum S-antigen repeat unit(s) or variant(s) thereof and b) at least one antigen different from the S-antigen. The present invention also relates to a pharmaceutical composition comprising that fusion polypeptide as well as to the use thereof for the treatment or prevention of an autoimmune disease, an allergic reaction, a transplantation-related complication, e.g. graft rejection or 'graft vs. host disease', and another inflammatory disease and a method for treatment or prevention of said conditions.
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2.发明公开
公开(公告)号：EP2198008A1
公开(公告)日：2010-06-23
申请号：EP08838013.4
申请日：2008-10-10
CPC分类号： G01N33/56972 , A61K2035/122 , C12N5/0636
摘要： The present invention relates to methods for isolating human forkhead box P3 (Foxp3+) CD4+ regulatory T cells (herein referred to as Foxp3+ Treg cells) from a sample containing (i) peripheral blood mononuclear cells (PBMCs), (ii) a lymphocyte containing fluid, or (iii) a lymphocyte containing tissue, a kit for isolating human Foxp3+ Treg cells, and the use of anti-CD49d antibody for the isolation of human Foxp3+ Treg cells.
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3.发明授权
公开(公告)号：EP2198008B1
公开(公告)日：2013-04-10
申请号：EP08838013.4
申请日：2008-10-10
CPC分类号： G01N33/56972 , A61K2035/122 , C12N5/0636
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