公开(公告)号：EP2197906A1

公开(公告)日：2010-06-23

申请号：EP08802876.6

申请日：2008-10-13

申请人： Max-Delbrück-Centrum für Molekulare Medizin (MDC) ,  Humboldt Universität zu Berlin

发明人： FALK, Kirsten ,  RÖTZSCHKE, Olaf ,  LUCIUS, Richard

IPC分类号： C07K14/445 ,  A61K39/002 ,  C12N15/62

CPC分类号： C07K14/445 ,  A61K39/0008 ,  A61K39/001 ,  A61K39/35 ,  A61K39/385 ,  C07K2319/40 ,  Y02A50/401 ,  Y02A50/412 ,  Y02A50/414

摘要： The present invention relates to a fusion polypeptide comprising a) at least one fragment of the Plasmodium falciparum S-antigen or a variant thereof, wherein the fragment comprises one or a plurality of Plasmodium falciparum S-antigen repeat unit(s) or variant(s) thereof and b) at least one antigen different from the S-antigen. The present invention also relates to a pharmaceutical composition comprising that fusion polypeptide as well as to the use thereof for the treatment or prevention of an autoimmune disease, an allergic reaction, a transplantation-related complication, e.g. graft rejection or 'graft vs. host disease', and another inflammatory disease and a method for treatment or prevention of said conditions.

公开(公告)号：EP3193920A2

公开(公告)日：2017-07-26

申请号：EP15763592.1

申请日：2015-09-16

申请人： Humboldt-Universität zu Berlin ,  Universiteit Utrecht Holding B.V.

发明人： GUPTA, Nishith ,  ARROYO-OLARTE, Ruben ,  LUCIUS, Richard ,  BROUWERS, Jos ,  HELMS, J. Bernd ,  DUNAY, Ildiko

IPC分类号： A61K39/02 ,  A61K35/68 ,  C12N9/12 ,  A61K39/012

摘要： A genetically modified coccidian parasites wherein expression of phosphatidylthreonine synthase (PTS) is disrupted, a polynucleotide including a nucleotide sequence encoding a phosphatidylthreonine synthase (PTS) enzyme, which catalyzes the production of a lipid, phosphatidylthreonine (PtdThr). PtdThr is an exclusive, major and physiologically important lipid in selected coccidian parasites, which is required for a normal growth and virulence of coccidian parasites. Coccidian parasites, having the expression of PTS disrupted as described herein, are useful as vaccines. The phosphatidylthreonine synthase enzyme and the nucleotide encoding sequences thereof as well as the phosphatidylthreonine phospholipid can find use in diagnostic methods and diagnostic kits or in vaccine and drug development applications.

摘要翻译： 本发明涉及其中磷脂酰 - 苏氨酸合酶（PTS）表达被破坏的遗传修饰的球虫寄生虫，包含编码磷脂酰 - 苏氨酸合酶（PTS）的核苷酸序列的多核苷酸，其催化产生脂质磷脂酰 - 苏氨酸（PtdThr）。 PtdThr是选定的球虫寄生虫中独有的，主要的和生理学上重要的脂质，这对于球虫寄生虫的正常生长和毒力是必需的。 如本文所述具有破坏的PTS表达的球虫寄生虫可用作疫苗。 磷脂酰苏氨酸合成酶及其核苷酸编码序列以及磷脂酰苏氨酸磷脂可用于诊断方法和诊断试剂盒或用于疫苗和药物开发应用。

公开(公告)号：EP3193920B1

公开(公告)日：2020-02-19

申请号：EP15763592.1

申请日：2015-09-16

申请人： Humboldt-Universität zu Berlin ,  Universiteit Utrecht Holding B.V.

发明人： GUPTA, Nishith ,  ARROYO-OLARTE, Ruben ,  LUCIUS, Richard ,  BROUWERS, Jos ,  HELMS, J. Bernd ,  DUNAY, Ildiko

IPC分类号： A61K39/02 ,  A61K35/68 ,  C12N9/12 ,  A61K39/012 ,  A61K39/00 ,  C12N1/10 ,  C12N1/36 ,  C07F9/10

公开(公告)号：EP2056867A2

公开(公告)日：2009-05-13

申请号：EP07786549.1

申请日：2007-08-03

申请人： Humboldt-Universität zu Berlin ,  Charité - Universitätsmedizin Berlin

发明人： HARTMANN, Susanne ,  LUCIUS, Richard ,  SCHNOELLER, Corinna ,  HAMELMANN, Eckard

IPC分类号： A61K38/57 ,  A61P37/00

CPC分类号： A61K38/57

摘要： The present invention relates to uses of cystatins derived from nematodes and to a method of screening using such cystatin. The present invention also relates to methods of treatment and/or prevention of an allergic and/or autoimmune disease in a patient, using a cystatin derived from a nematode.