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公开(公告)号：EP1300158A1
公开(公告)日：2003-04-09
申请号：EP01943840.7
申请日：2001-06-27
IPC分类号： A61K45/00 , A61K48/00 , A61K31/711 , A61K38/18 , A61K31/5585 , A61P9/00 , A61P9/10
CPC分类号： A61K38/52 , A61K31/5585 , A61K31/711 , A61K38/1709 , A61K38/1833 , A61K38/1858 , A61K48/00 , A61K2300/00
摘要： The present invention provides: (1) pharmaceutical compositions for angiogenic therapy which contain, as the active ingredients, at least one substance selected from substances having vasodilating effect and/or platelet aggregation inhibitory effect, and substances producing them; and a gene encoding an angiogenesis factor; (2) agents for potentiating the angiogenic effect of a gene encoding an angiogenesis factor that contain, as the active ingredient, at least one substance selected from substances having vasodilating effect and/or platelet aggregation inhibitory effect and substances producing them; (3) an angiogenic agent which contains a prostacyclin synthase gene as the active ingredient; (4) pharmaceutical compositions for angiogenic therapy which contain ets-1 gene and another gene encoding an angiogenesis factor as the active ingredients; (4) an agent which contain ets-1 gene as the active ingredient for potentiating the angiogenic effect of another gene encoding an angiogenesis factor; and (5) an angiogenic agent which contains ets-1 gene as the active ingredient.
摘要翻译： 本发明提供：（1）血管生成治疗用药物组合物，其含有选自具有血管扩张作用和/或血小板聚集抑制作用的物质中的至少一种物质作为活性成分，以及生成它们的物质; 和编码血管生成因子的基因; （2）用于增强编码血管生成因子的基因的血管生成作用的药剂，其含有选自具有血管扩张作用和/或血小板聚集抑制作用的物质和/或血小板聚集抑制作用的物质中的至少一种物质作为活性成分; （3）含有前列环素合酶基因作为活性成分的血管生成剂; （4）含有ets-1基因和编码血管生成因子的另一基因作为活性成分的用于血管生成治疗的药物组合物; （4）含有ets-1基因作为增强编码血管生成因子的另一基因的血管生成作用的活性成分的药剂; 和（5）含有ets-1基因作为活性成分的血管发生剂。
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公开(公告)号：EP1300158B9
公开(公告)日：2008-11-19
申请号：EP01943840.7
申请日：2001-06-27
申请人： AnGes MG, Inc. , Morishita, Ryuichi
CPC分类号： A61K38/52 , A61K31/5585 , A61K31/711 , A61K38/1709 , A61K38/1833 , A61K38/1858 , A61K48/00 , A61K2300/00
摘要： Medicinal compositions for angiogenic therapy which contain as the active ingredients at least one member selected from among substances having a vasodilating effect and/or a platelet aggregation inhibitory effect and substances producing the same, and a gene encoding an angiogenesis factor; agents for potentiating the angiogenic effect of a gene encoding an angiogenesis factor which contain as the active ingredient at least one member selected from among substances having a vasodilating effect and/or a platelet aggregation inhibitory effect and substances producing the same; an angiogenic agent which contains prostacyclin synthase gene as the active ingredient; medicinal compositions for angiogenic therapy which contain ets-1 gene and another gene encoding an angiogenesis factor as the active ingredients; an agent for potentiating the angiogenic effect of a gene encoding an angiogenesis factor which contain ets-1 gene as the active ingredient; and an angiogenic agent which contains ets-1 gene as the active ingredient.
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公开(公告)号：EP1300158B1
公开(公告)日：2008-05-14
申请号：EP01943840.7
申请日：2001-06-27
申请人： AnGes MG, Inc. , Morishita, Ryuichi
CPC分类号： A61K38/52 , A61K31/5585 , A61K31/711 , A61K38/1709 , A61K38/1833 , A61K38/1858 , A61K48/00 , A61K2300/00
摘要： Medicinal compositions for angiogenic therapy which contain as the active ingredients at least one member selected from among substances having a vasodilating effect and/or a platelet aggregation inhibitory effect and substances producing the same, and a gene encoding an angiogenesis factor; agents for potentiating the angiogenic effect of a gene encoding an angiogenesis factor which contain as the active ingredient at least one member selected from among substances having a vasodilating effect and/or a platelet aggregation inhibitory effect and substances producing the same; an angiogenic agent which contains prostacyclin synthase gene as the active ingredient; medicinal compositions for angiogenic therapy which contain ets-1 gene and another gene encoding an angiogenesis factor as the active ingredients; an agent for potentiating the angiogenic effect of a gene encoding an angiogenesis factor which contain ets-1 gene as the active ingredient; and an angiogenic agent which contains ets-1 gene as the active ingredient.
摘要翻译： 含有选自具有血管舒张作用和/或血小板聚集抑制作用的物质中的至少一种作为有效成分的血管生成疗法用药物组合物及其制造物质和编码血管生成因子的基因， 包含作为活性成分的选自具有血管舒张作用和/或血小板凝集抑制作用的物质中的至少一种的物质和产生该物质的物质的增强编码血管发生因子的基因的血管生成作用的试剂; 含有前列环素合酶基因作为活性成分的血管生成剂; 包含ets-1基因和编码血管生成因子的另一基因作为活性成分的用于血管生成治疗的药物组合物; 用于增强编码血管生成因子的基因的血管生成作用的试剂，该基因含有作为活性成分的ets-1基因; 和含有ets-1基因作为活性成分的血管生成剂。
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