公开(公告)号：EP2142540A2

公开(公告)日：2010-01-13

申请号：EP08719386.8

申请日：2008-03-28

申请人： Medichem S.A.

发明人： PUIG SERRANO, Jordi ,  CAMPS, Pelayo

IPC分类号： C07D453/02

CPC分类号： C07D403/10

摘要： The present invention provides an improved synthetic strategy for the preparation of solifenacin and pharmaceutically acceptable salts thereof.

公开(公告)号：EP4110832A1

公开(公告)日：2023-01-04

申请号：EP21701240.0

申请日：2021-01-13

申请人： Medichem, S.A.

发明人： PUIG SERRANO, Jordi ,  DURAN LÓPEZ, Ernesto ,  MARKALAIN BARTA, Jordi ,  FERREIRA DA COSTA, Joana Raquel

IPC分类号： C08B37/16 ,  A61K31/724 ,  C08L5/16

公开(公告)号：EP3178824A1

公开(公告)日：2017-06-14

申请号：EP16382592.0

申请日：2016-12-07

申请人： Medichem, S.A. ,  BrightGene Bio-Medical Technology Co., Ltd.

发明人： JIANDONG, Yuan ,  YANGQING, Huang ,  JIANWEN, Chi ,  LIANG, Ge ,  CARRERAS I VILAGRAN, Marçal ,  PUIG SERRANO, Jordi

IPC分类号： C07D498/18

CPC分类号： C07D498/18

摘要： The present invention is related to an improved industrially applicable process for preparing pimecrolimus from ascomycin. This process shows significantly high yields, so that purification of the pimecrolimus can be accomplished by crystallization, not requiring for example of chromatographic purifications.

摘要翻译： 本发明涉及由子囊霉素制备吡美莫司的改进的工业上可用的方法。 该方法显示出非常高的收率，因此可以通过结晶完成匹美莫司的纯化，而不需要例如色谱纯化。

公开(公告)号：EP3717521A1

公开(公告)日：2020-10-07

申请号：EP18804644.5

申请日：2018-11-26

申请人： Medichem, S.A.

发明人： PUIG SERRANO, Jordi ,  BOSCH I LLADO, Jordi ,  NG CHOI, Iteng ,  DURAN LÓPEZ, Ernesto

IPC分类号： C08B37/16

公开(公告)号：EP1902010A2

公开(公告)日：2008-03-26

申请号：EP06848698.4

申请日：2006-06-16

申请人： Medichem, S.A.

发明人： PUIG SERRANO, Jordi

IPC分类号： C07C43/21 ,  C07C65/26

CPC分类号： C07C65/26 ,  C07C51/02 ,  C07C51/09 ,  C07C51/412 ,  C07C51/43 ,  C07C51/47 ,  C07C51/50 ,  C07C67/343 ,  C07C2603/74 ,  C07C69/94

摘要： The invention provides an improved process for the preparation of a benzonaphthalene derivative including, in particular, the manufacture of high purity adapalene. The invention further includes a method for assessing the color of adapalene by means of a quantitative colorimetric measurement of the produced adapalene.

公开(公告)号：EP4452236A2

公开(公告)日：2024-10-30

申请号：EP22797399.7

申请日：2022-10-27

申请人： Medichem, S.A.

发明人： FERNÁNDEZ GARROSA, Isabel ,  SUÑÉ POU, Marc ,  DURÁN LÓPEZ, Ernesto ,  LOZANO VELILLA, José Andrés ,  PUIG SERRANO, Jordi

IPC分类号： A61K9/20 ,  A61K31/55 ,  A61P25/34

公开(公告)号：EP1902010B1

公开(公告)日：2011-11-30

申请号：EP06848698.4

申请日：2006-06-16

申请人： Medichem, S.A.

发明人： PUIG SERRANO, Jordi

IPC分类号： C07C43/21 ,  C07C65/26

CPC分类号： C07C65/26 ,  C07C51/02 ,  C07C51/09 ,  C07C51/412 ,  C07C51/43 ,  C07C51/47 ,  C07C51/50 ,  C07C67/343 ,  C07C2603/74 ,  C07C69/94

摘要： The invention provides an improved process for the preparation of a benzonaphthalene derivative including, in particular, the manufacture of high purity adapalene. The invention further includes a method for assessing the color of adapalene by means of a quantitative colorimetric measurement of the produced adapalene.

摘要翻译： 本发明提供了一种制备苯并萘衍生物的改进方法，特别是制备高纯度阿达帕林。 本发明还包括通过所产生的阿达帕林的定量比色测量来评估阿达帕林的颜色的方法。

公开(公告)号：EP2064205A2

公开(公告)日：2009-06-03

申请号：EP07825063.6

申请日：2007-09-07

申请人： Medichem, S.A.

发明人： SOLEVILLA MADRID, Nuria ,  DURAN LOPEZ, Ernesto ,  PUIG SERRANO, Jordi

IPC分类号： C07D405/06

CPC分类号： C07D405/06

摘要： A process for preparing substituted pyrrolidine compounds, including (5)-2-{l-[2- (2,3-dihydrobenzofuran-5-yl)ethyl]-3-pyrrolidinyl}-2,2-diphenylacetamide hydrobromide, commonly known in the art as darifenacin, comprising reacting a pyrrolidine compound with a benzofuran derivative in the presence of a phase-transfer catalyst.

公开(公告)号：EP1799678A1

公开(公告)日：2007-06-27

申请号：EP05797070.9

申请日：2005-09-15

申请人： Medichem, S.A.

发明人： BURGAROLAS MONTERO, Carme ,  PUIG SERRANO, Jordi ,  ARNALOT AGUILAR, Carme ,  BOSCH ILLADO, Jordi

IPC分类号： C07D417/12 ,  A61K31/428 ,  A61P25/18

CPC分类号： C07D417/12

摘要： The present invention concerns a process for the preparation of 5-(2-(4-(1,2- 5 benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one of the formula (I), or a pharmaceutically acceptable acid addition salt, solvate, hydrates or clathrate thereof, said process comprising reacting a compound of formula (II) wherein X is a halogen atom, with a compound of formula (III), said compound of formula (III) being the free base or an addition salt with an organic or inorganic acid, wherein said process is characterized in that said compounds according to formulas (II) and (III) are reacted in the presence of a neutralizing agent, and are reacted in a solvent comprising acetonitrile.