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    GAMMA-CYCLODEXTRIN OLIGOMER FOR USE IN TREATING CHRONIC KIDNEY DISEASE
    1.
    发明公开
    GAMMA-CYCLODEXTRIN OLIGOMER FOR USE IN TREATING CHRONIC KIDNEY DISEASE 审中-实审

    公开(公告)号：EP4335443A1

    公开(公告)日：2024-03-13

    申请号：EP23172543.3

    申请日：2023-05-10

    申请人： Renatus Inc.

    发明人： KIM, Hee Gon

    IPC分类号： A61K31/724 ,  A61P13/12

    摘要： Provided are a method of treating chronic kidney disease or one or more symptoms thereof, or reducing a complication related to chronic kidney disease, the method comprising, administering a therapeutically effective amount of gamma-cyclodextrin oligomer to a subject in need thereof. The gamma-cyclodextrin oligomers are effective in cholesterol metabolism enhancement, cholesterol efflux, reducing inflammatory cytokine secretion, renal clearance of cholesterol and/or reducing albuminuria. Therefore, the gamma-cyclodextrin oligomers can be used to treat or alleviate chronic kidney disease, symptoms thereof and/or a complication related to chronic kidney disease.

    INTESTINAL TRACT FUNCTION IMPROVING AGENT
    6.
    发明公开
    INTESTINAL TRACT FUNCTION IMPROVING AGENT 审中-公开

    公开(公告)号：EP4115950A1

    公开(公告)日：2023-01-11

    申请号：EP21763653.9

    申请日：2021-03-01

    申请人： Cyclochem Bio Co., Ltd.

    发明人： TERAO Keiji ,  CHIKAMOTO Keita ,  FURUNE Takahiro ,  NANRI Ayumi ,  YOSHIKAWA Yutaka

    IPC分类号： A61P1/00 ,  A61P1/10 ,  A61P37/04 ,  A23L33/125 ,  A61K31/724

    摘要： An agent which can play a comparable or superior role to LS in improvement of intestinal tract function, enhancement of immune function, suppression of production of a putrefactive product, improvement of bowel movement or the like and an agent which can play a role in protection of the intestinal tract from a food emulsifier, a lipid peroxide or the like are provided. An intestinal tract function-improving agent, an immunoenhancing agent, a putrefactive product production-suppressing agent, a bowel movement-improving agent and an intestinal tract protection agent each containing a cyclodextrin as an active ingredient are provided. they can play a comparable or superior role to LS in improvement of intestinal tract function, enhancement of immune function, suppression of production of a putrefactive products, improvement of bowel movement or the like and the agent which can play a role in protection of the intestinal tract from a food emulsifier, a lipid peroxide or the like. Using the agents as an active ingredient, an anti-inflammatory agent, an immunostimulant, a body odor-improving agent, a stool odor-improving agent, a laxative, an intestinal tract protection agent and the like can also be provided.

    INJECTION FORMULATION
    7.
    发明公开
    INJECTION FORMULATION 审中-公开

    公开(公告)号：EP4023292A1

    公开(公告)日：2022-07-06

    申请号：EP20859347.5

    申请日：2020-06-25

    申请人： TERUMO Kabushiki Kaisha

    发明人： YOSHIKAWA, Hiroki ,  ITO, Hiroshi ,  YAMAMOTO, Satoshi

    IPC分类号： A61P21/00 ,  A61K9/08 ,  A61J1/00 ,  A61J1/05 ,  A61K31/724

    摘要： [Problem] To provide a sugammadex sodium injection formulation capable of suppressing fluctuations in foreign substances such as analog substances and being stably preserved for a long period of time. [Solution] An injection formulation comprising: a medical container having an oxygen-permeable container, in which a sugammadex sodium aqueous solution containing sugammadex sodium as an active ingredient is filled and under undergoes high pressure steam sterilization; and an oxygen permeation-retardant packaging container, wherein (i) the medical container is accommodated and hermetically sealed, together with an oxygen scavenger, inside the oxygen permeation-retardant packaging container, or (ii) the medical container is accommodated and hermetically sealed inside the oxygen permeation-retardant packaging container, into which an inert gas has been substituted.