利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

3 条记录 (耗时 0.016 秒)

    TARGETING CYTOTOXIC CELLS WITH CHIMERIC RECEPTORS FOR ADOPTIVE IMMUNOTHERAPY
    1.
    发明公开
    TARGETING CYTOTOXIC CELLS WITH CHIMERIC RECEPTORS FOR ADOPTIVE IMMUNOTHERAPY 审中-公开

    公开(公告)号：EP3623380A1

    公开(公告)日：2020-03-18

    申请号：EP19187938.6

    申请日：2014-03-15

    申请人： Milone, Michael C. ,  Wang, Enxiu

    发明人： Milone, Michael C. ,  Wang, Enxiu

    IPC分类号： C07K14/705 ,  C07K19/00

    摘要： The present invention provides compositions and methods for regulating the specificity and activity of T cells. In one embodiment, the invention provides a type of chimeric antigen receptor (CAR) wherein the CAR is termed a "KIR-CAR" which is a CAR design comprising a component of a receptor naturally found on natural killer (NK) cells. In one embodiment, the NK receptor includes but is not limited to a naturally occurring activating and inhibitory receptor of NK cells known as a killer cell immunoglobulin-like receptor (KIR).

    TARGETING CYTOTOXIC CELLS WITH CHIMERIC RECEPTORS FOR ADOPTIVE IMMUNOTHERAPY
    3.
    发明公开
    TARGETING CYTOTOXIC CELLS WITH CHIMERIC RECEPTORS FOR ADOPTIVE IMMUNOTHERAPY 审中-公开
    ANZIELUNG ZYTOTOXISCHER ZELLEN MITCHIMÄRENREZEPTORENFÜREINE ADOPTIVE IMMUNTHERAPIE

    公开(公告)号：EP2970426A2

    公开(公告)日：2016-01-20

    申请号：EP14722891.0

    申请日：2014-03-15

    申请人： Milone, Michael C. ,  Wang, Enxiu

    发明人： Milone, Michael C. ,  Wang, Enxiu

    IPC分类号： C07K14/705 ,  C07K19/00

    CPC分类号： C07K16/18 ,  C07K14/70503 ,  C07K14/70535 ,  C07K2319/03 ,  C07K2319/33 ,  C07K2319/70

    摘要： The present invention provides compositions and methods for regulating the specificity and activity of T cells. In one embodiment, the invention provides a type of chimeric antigen receptor (CAR) wherein the CAR is termed a “KIR-CAR” which is a CAR design comprising a component of a receptor naturally found on natural killer (NK) cells. In one embodiment, the NK receptor includes but is not limited to a naturally occurring activating and inhibitory receptor of NK cells known as a killer cell immunoglobulin-like receptor (KIR).

    摘要翻译： 本发明提供调节T细胞的特异性和活性的组合物和方法。 在一个实施方案中，本发明提供了一种嵌合抗原受体（CAR），其中CAR被称为“KIR-CAR”，其是包含天然杀伤（NK）细胞天然存在的受体成分的CAR设计。 在一个实施方案中，NK受体包括但不限于称为杀伤细胞免疫球蛋白样受体（KIR）的NK细胞的天然存在的活化和抑制性受体。