公开(公告)号：EP3246322A4

公开(公告)日：2018-07-25

申请号：EP15877758

申请日：2015-12-15

申请人： NATIONAL UNIV CORPORATION KOBE UNIV

发明人： MATSUBARA RYOSUKE ,  ANDO AKIHIRO ,  HAYASHI MASAHIKO

IPC分类号： C07D271/08 ,  A61K31/4245 ,  A61P9/10 ,  A61P25/08 ,  A61P25/28 ,  A61P35/00

CPC分类号： C07D271/08 ,  A61K31/4245

摘要： The present invention provides: a furoxan compound having a fluorine atom as a substituent group on the ring structure thereof; and a novel nitric oxide donor including the compound. The present invention relates to a fluorofuroxan compound represented by general formula (1) or (2). The compound of formula (1) can be manufactured by reacting a fluoride salt with a nitrofuroxan compound to substitute the nitro group with a fluoro group. The compound of formula (2) can be manufactured by subjecting the compounds of formula (1) to isomerization by irradiation with light.