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    NOVEL 1,4-DIAZA-BICYCLOÝ3.2.2¨NONYL PYRIMIDINYL DERIVATIVES AND THEIR MEDICAL USE
    2.
    发明公开
    NOVEL 1,4-DIAZA-BICYCLOÝ3.2.2¨NONYL PYRIMIDINYL DERIVATIVES AND THEIR MEDICAL USE 审中-公开
    新型1,4-二氮杂双环[3.2.2]壬基嘧啶衍生物及其医疗用途

    公开(公告)号：EP2041134A1

    公开(公告)日：2009-04-01

    申请号：EP07729592.1

    申请日：2007-05-29

    申请人： NeuroSearch A/S

    发明人： PETERS, Dan ,  OLSEN, Gunnar, M. ,  NIELSEN, Elsebet, Østergaard ,  TIMMERMANN, Daniel, B. ,  LOECHEL, Steven, Charles ,  CHRISTENSEN, Jeppe, Kejser ,  MIKKELSEN, Jens, Damsgaard ,  HANSEN, Henrik, Björk ,  REDROBE, John, Paul ,  DYHRING, Tino

    IPC分类号： C07D471/08 ,  A61K31/551 ,  A61P25/00

    CPC分类号： C07D471/08

    摘要： This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及新的1,4-二氮杂 - 双环[3.2.2]壬基嘧啶基衍生物及其在制备药物组合物中的用途。 发现本发明的化合物是烟碱乙酰胆碱受体上的胆碱能配体和单胺受体和转运蛋白的调节剂。 由于它们的药理学特征，本发明的化合物可用于疾病或病症等不同的那些涉及到中枢神经系统（CNS），外周神经系统（PNS）的疾病或相关病症的胆碱能系统的治疗有用 平滑肌收缩，内分泌疾病或病症，与神经变性有关的疾病或病症，与炎症相关的疾病或病症，由化学物质滥用终止引起的疼痛和戒断症状。

    NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES AND THEIR MEDICAL USE
    3.
    发明公开
    NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES AND THEIR MEDICAL USE 有权
    NEW 1,4-二氮杂双环[3.2.2]壬基二唑基衍生物和其医疗用途

    公开(公告)号：EP2032575A1

    公开(公告)日：2009-03-11

    申请号：EP07729591.3

    申请日：2007-05-29

    申请人： NEUROSEARCH A/S

    发明人： PETERS, Dan ,  OLSEN, Gunnar, M. ,  NIELSEN, Elsebet, Østergaard ,  TIMMERMANN, Daniel, B. ,  LOECHEL, Steven, Charles

    IPC分类号： C07D471/08 ,  A61K31/551 ,  A61P25/00

    CPC分类号： C07D471/08

    摘要： This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances. Ar represents a phenyl group, which phenyl is substituted with methylenedioxy or ethylenedioxy.

    NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL PYRIMIDINYL DERIVATIVES AND THEIR MEDICAL USE
    6.
    发明公开
    NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL PYRIMIDINYL DERIVATIVES AND THEIR MEDICAL USE 审中-公开
    NEW 1,4-二氮杂双环[3.2.2] NONYLPYRIMIDINYLDERIVATE及其医学用途

    公开(公告)号：EP2049538A1

    公开(公告)日：2009-04-22

    申请号：EP07729593.9

    申请日：2007-05-29

    申请人： NeuroSearch A/S

    发明人： PETERS, Dan ,  OLSEN, Gunnar, M. ,  NIELSEN, Elsebet, Østergaard ,  TIMMERMANN, Daniel, B. ,  LOECHEL, Steven, Charles

    IPC分类号： C07D471/08 ,  A61K31/551 ,  A61P25/00

    CPC分类号： C07D471/08

    摘要： This invention relates to a novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivative and its use in the manufacture of pharmaceutical compositions. The compound of the invention is found to be a cholinergic ligand at the nicotinic acetylcholine receptors. Due to its pharmacological profile the compound of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    NOVEL DIAZABICYCLIC ARYL DERIVATIVES AS CHOLINERGY LIGANDS
    9.
    发明授权
    NOVEL DIAZABICYCLIC ARYL DERIVATIVES AS CHOLINERGY LIGANDS 有权
    新型二氮杂双环芳基衍生物作为配位体的胆碱能

    公开(公告)号：EP1819709B1

    公开(公告)日：2009-02-11

    申请号：EP05817438.4

    申请日：2005-11-29

    申请人： NEUROSEARCH A/S

    发明人： PETERS, Dan ,  TIMMERMANN, Daniel, B. ,  OLSEN, Gunnar, M. ,  NIELSEN, Elsebet, Østergaard ,  JØRGENSEN, Tino, Dyhring

    IPC分类号： C07D487/08 ,  A61K31/4995 ,  A61P25/00

    CPC分类号： C07D487/08

    摘要： This invention relates to novel diazabicyclic aryl derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.