公开(公告)号：EP2457991A1

公开(公告)日：2012-05-30

申请号：EP10802340.9

申请日：2010-07-23

申请人： NIPRO CORPORATION ,  Reprocell Incorporated

发明人： MORIMOTO, Shinji ,  HAGIWARA, Yui

IPC分类号： C12M1/34 ,  G01N27/28 ,  G01N27/416

CPC分类号： B01L3/5085 ,  B01L2300/0645 ,  B01L2300/0829 ,  G01N33/4836

摘要： An object of the present invention is to provide a cellular electric potential measuring container with which an accurate measurement result can be readily obtained by bringing a cell into contact with a fine measurement electrode in cellular electric potential measurement using a cellular electric potential measuring container. The present invention provides a cellular electric potential measuring container comprising a container body and an electrode substrate, the electrode substrate being attached to a lower end of the container body so as to form a plurality of wells, the cellular electric potential measuring container being for measuring cellular electric potential after being mounted on an electric potential measuring device and, wherein the container body is made from resin and comprises a plurality of tubular portions whose upper and lower ends are open, each of the tubular portions comprises in an inner cavity a measurement portion tapered toward the lower end and having a measurement hole at the lower end, and further on an inner wall at least two retaining means retaining the measurement portion, the electrode substrate comprises a substrate body, with a plurality of measurement electrodes and a plurality of reference electrodes being disposed on one surface of the substrate body, and the container body is attached to the surface of the substrate body on which the measurement electrodes and the reference electrodes are disposed, such that the measurement electrodes are respectively exposed through the measurement holes.

摘要翻译： 本发明的目的是提供一种蜂窝电位测量容器，通过使用细胞电位测量容器在细胞电位测量中使细胞与细测量电极接触，可以容易地获得准确的测量结果。 本发明提供一种蜂窝电位测量容器，其包括容器主体和电极基板，所述电极基板安装在容器主体的下端以形成多个孔，所述蜂窝电位测量容器用于测量 蜂窝电位被安装在电位测量装置上，并且其中容器主体由树脂制成并且包括多个上端和下端开放的管状部分，每个管状部分在内腔中包括测量部分 在下端呈锥形并在下端具有测量孔，并且在内壁上还有至少两个保持测量部分的保持装置，电极基板包括具有多个测量电极和多个参考的基板主体 电极设置在基板主体的一个表面上，以及容器 主体附接到其上设置有测量电极和参考电极的基板主体的表面，使得测量电极分别通过测量孔露出。

公开(公告)号：EP2508875A1

公开(公告)日：2012-10-10

申请号：EP10834509.1

申请日：2010-11-22

申请人： Nipro Corporation

发明人： MORIMOTO, Shinji ,  HAGIWARA, Yui

IPC分类号： G01N27/28 ,  C12M1/34 ,  G01N27/30 ,  G01N27/416

CPC分类号： C12M41/46 ,  C12M23/12

摘要： An object of the present invention is to provide a cellular electric potential measuring container with which an accurate measurement result can be obtained without weakening or killing the cells to be measured in cellular electric potential measurement using a cellular electric potential measuring container. The present invention provides a container for measuring cellular electric potential after being mounted on an electric potential measuring device, comprising a container and an electrode substrate, the electrode substrate being attached to a lower end of the container so as to form a plurality of wells, wherein the container comprises a plurality of cylindrical portions whose upper and lower ends are open, the electrode substrate comprises a substrate and a plurality of measurement electrodes and a plurality of reference electrodes disposed on one surface of the substrate, the measurement electrodes and the reference electrodes at least comprise metal-plated copper wiring, a pair of a measurement electrode and a reference electrode are disposed on a bottom of each well, and the measurement electrodes and the reference electrodes are formed by a pre-plating method.

公开(公告)号：EP2829288B1

公开(公告)日：2018-08-15

申请号：EP13765200.4

申请日：2013-01-29

申请人： Nipro Corporation

发明人： SASAYAMA, Norihisa ,  HAGIWARA, Yui ,  ISHIHARA, Naoko

IPC分类号： A61M1/02 ,  A61M5/31 ,  A61M5/315 ,  A61M5/32 ,  A61M5/178 ,  A61M1/00

CPC分类号： A61M39/10 ,  A61M1/029 ,  A61M5/178 ,  A61M5/31515 ,  A61M5/3202 ,  A61M5/3275 ,  A61M2005/3268

摘要： [Object] To prevent a user from accidentally pricking the user with a hollow needle when separating blood components using a syringe and a connection device. [Solution] A blood component separation apparatus has three syringes and a connection device 14. The connection device 14 is attached to one syringe and is inserted into other syringes. The connection device 14 has a first member 40 to which a base end of a hollow needle 17 is joined and a second member 60 which is connected to the first member 40 in such a manner as to be able to move relative to the first member 40. The second member 60 is moved back and forth between a first position where a tip 18 of the hollow needle 17 is accommodated and a second position where the tip 18 of the hollow needle 17 is exposed. The second member 60 has elastic portions 63 which are elastically deformed in the movement from the first position to the second position. The elastically deformed elastic portions 63 elastically energize the second member 60 at the second position to the first position side with respect to the first member 40.

公开(公告)号：EP2829288A1

公开(公告)日：2015-01-28

申请号：EP13765200.4

申请日：2013-01-29

申请人： Nipro Corporation

发明人： SASAYAMA, Norihisa ,  HAGIWARA, Yui ,  ISHIHARA, Naoko

IPC分类号： A61M1/02 ,  A61M5/31

CPC分类号： A61M39/10 ,  A61M1/029 ,  A61M5/178 ,  A61M5/31515 ,  A61M5/3202 ,  A61M5/3275 ,  A61M2005/3268

摘要： [Object] To prevent a user from accidentally pricking the user with a hollow needle when separating blood components using a syringe and a connection device.
[Solution] A blood component separation apparatus has three syringes and a connection device 14. The connection device 14 is attached to one syringe and is inserted into other syringes. The connection device 14 has a first member 40 to which a base end of a hollow needle 17 is joined and a second member 60 which is connected to the first member 40 in such a manner as to be able to move relative to the first member 40. The second member 60 is moved back and forth between a first position where a tip 18 of the hollow needle 17 is accommodated and a second position where the tip 18 of the hollow needle 17 is exposed. The second member 60 has elastic portions 63 which are elastically deformed in the movement from the first position to the second position. The elastically deformed elastic portions 63 elastically energize the second member 60 at the second position to the first position side with respect to the first member 40.

摘要翻译： 背景技术为了防止使用注射器和连接装置分离血液成分时用户用空心针不小心刺破使用者。 [血液成分分离装置]血液成分分离装置具有三个注射器和连接装置14.连接装置14安装在一个注射器上，插入其他注射器。 连接装置14具有第一构件40和第二构件60，第一构件40连接到中空针17的基端，第二构件60以能够相对于第一构件40移动的方式连接到第一构件40 第二构件60在容纳中空针17的末端18的第一位置和中空针17的末端18暴露的第二位置之间来回移动。 第二构件60具有在从第一位置到第二位置的运动中弹性变形的弹性部分63。 弹性变形的弹性部分63在第二位置处将第二构件60弹性地激励至相对于第一构件40的第一位置侧。

公开(公告)号：EP2458373A1

公开(公告)日：2012-05-30

申请号：EP10802341.7

申请日：2010-07-23

申请人： NIPRO CORPORATION

发明人： MORIMOTO, Shinji ,  HAGIWARA, Yui

IPC分类号： G01N27/30 ,  C12M1/34 ,  G01N27/28 ,  G01N27/416

CPC分类号： G01N33/48728

摘要： An object of the present invention is to provide a cellular electric potential measuring container with which no wavy baseline occurs and an accurate measurement result can be readily obtained in cellular electric potential measurement using a cellular electric potential measuring container. The present invention provides a cellular electric potential measuring container comprising a container body and an electrode substrate, the electrode substrate being attached to a lower end of the container body so as to form a plurality of wells, the cellular electric potential measuring container being for measuring cellular electric potential after being mounted on an electric potential measuring device, wherein the container body comprises: a plurality of tubular portions whose upper and lower ends are open, and a portion reserved for attachment at the lower end, the electrode substrate comprises a substrate body, with a plurality of measurement electrodes and a plurality of reference electrodes being disposed on one surface of the substrate body, and the container body is attached by a double-sided tape to the surface of the substrate body on which the measurement electrodes and the reference electrodes are disposed, at a place of the portion reserved for attachment, and a method for producing a cellular electric potential measuring container.

摘要翻译： 本发明的目的是提供一种细胞电位测量容器，其中没有波浪基线发生，并且在使用蜂窝电位测量容器的细胞电位测量中可以容易地获得准确的测量结果。 本发明提供一种蜂窝电位测量容器，其包括容器主体和电极基板，所述电极基板安装在容器主体的下端以形成多个孔，所述蜂窝电位测量容器用于测量 在电位测量装置上安装蜂窝电位，其中容器主体包括：多个管状部分，其上端和下端是开放的，并且保留用于在下端附着的部分，电极基片包括基体 ，多个测量电极和多个参考电极设置在基板主体的一个表面上，并且容器主体通过双面胶带附接到其上具有测量电极和参考的基板主体的表面 电极设置在保留用于附接的部分的位置，以及一种方法 用于生产细胞电位测量容器。