公开(公告)号：EP1458352A1

公开(公告)日：2004-09-22

申请号：EP02787456.9

申请日：2002-12-17

申请人： NOVO NORDISK A/S

发明人： HANSEN, Henrik, Egesborg ,  SABRA, Mads, Christian ,  RASMUSSEN, Thomas, Buch

IPC分类号： A61K9/00 ,  A61K47/14 ,  A61K38/28 ,  A61K9/36

CPC分类号： A61K9/0092 ,  A61K9/0024

摘要： A solid pharmaceutical composition for parenteral administration comprising an inner matrix comprising at least one therapeutic agent, and a biodegradable, and water-impermeable coating covering part of the surface of said composition,wherein said inner matrix disintegrates upon contact with animal tissue or tissue fluids. The coating is made from a material selected from the group consisting of polyesters such as polyglycolides, polylactides and polylactic polyglycolic acid copolymers (PLGA) etc. The innermatrix may comprise a binder, e.g. mannitol, and the active agent may comprise insulin.