公开(公告)号：EP2488640A1

公开(公告)日：2012-08-22

申请号：EP10823705.8

申请日：2010-10-14

申请人： Nanyang Technological University

发明人： TAN, Nguan, Soon ,  CHONG, Han, Chung ,  TAN, Ming, Jie ,  HUANG, Royston

IPC分类号： C12N15/00 ,  C12N15/113 ,  C07K16/00 ,  A61P35/00 ,  A61K31/7088 ,  A61K39/395

CPC分类号： C12N15/1136 ,  A61K2039/505 ,  C07K16/22 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2330/50

摘要： The invention provides an antibody specific to the ANGPTL4 protein capable of neutralizing proliferation and methods of making and using the same. The antibody of the invention is further directed to the C terminal region of the protein and may be capable of neutralizing cell proliferation and treating cancer. The antibody may be monoclonal and or humanized antibody.

公开(公告)号：EP2488640B1

公开(公告)日：2018-09-26

申请号：EP10823705.8

申请日：2010-10-14

申请人： Nanyang Technological University

发明人： TAN, Nguan, Soon ,  CHONG, Han, Chung ,  TAN, Ming, Jie ,  HUANG, Royston

IPC分类号： C12N15/00 ,  C12N15/113 ,  C07K16/00 ,  A61P35/00 ,  A61K31/7088 ,  A61K39/395

CPC分类号： C12N15/1136 ,  A61K2039/505 ,  C07K16/22 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2330/50

摘要： The invention provides an antibody specific to the ANGPTL4 protein capable of neutralizing proliferation and methods of making and using the same. The antibody of the invention is further directed to the C terminal region of the protein and may be capable of neutralizing cell proliferation and treating cancer. The antibody may be monoclonal and or humanized antibody.