公开(公告)号：EP2488640B1

公开(公告)日：2018-09-26

申请号：EP10823705.8

申请日：2010-10-14

申请人： Nanyang Technological University

发明人： TAN, Nguan, Soon ,  CHONG, Han, Chung ,  TAN, Ming, Jie ,  HUANG, Royston

IPC分类号： C12N15/00 ,  C12N15/113 ,  C07K16/00 ,  A61P35/00 ,  A61K31/7088 ,  A61K39/395

CPC分类号： C12N15/1136 ,  A61K2039/505 ,  C07K16/22 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2330/50

摘要： The invention provides an antibody specific to the ANGPTL4 protein capable of neutralizing proliferation and methods of making and using the same. The antibody of the invention is further directed to the C terminal region of the protein and may be capable of neutralizing cell proliferation and treating cancer. The antibody may be monoclonal and or humanized antibody.

公开(公告)号：EP3356531A1

公开(公告)日：2018-08-08

申请号：EP16852730.7

申请日：2016-09-30

申请人： APSE LLC

发明人： ARHANCET, Juan, P. H.

IPC分类号： C12N15/113 ,  C12N15/82

CPC分类号： C12N15/113 ,  C12N15/111 ,  C12N15/8218 ,  C12N15/8286 ,  C12N2310/14 ,  C12N2310/15 ,  C12N2320/32 ,  C12N2330/50 ,  Y02A40/162

摘要： The invention describes recombinant DNA sequences transcribed into RNA constructs capable of forming pseudoknots and being encapsidated in Virus Like Particles having higher insect control efficacy than previously described RNA molecules.

公开(公告)号：EP3218386A4

公开(公告)日：2018-07-18

申请号：EP15859587

申请日：2015-11-13

申请人： VOYAGER THERAPEUTICS INC

发明人： HOU JINZHAO ,  NONNENMACHER MATHIEU E ,  ZHOU PENGCHENG

IPC分类号： C07H21/02 ,  C12N15/113 ,  C12N15/85

CPC分类号： C12N15/1137 ,  C12N7/00 ,  C12N15/111 ,  C12N15/86 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/34 ,  C12N2310/531 ,  C12N2330/50 ,  C12N2750/14121 ,  C12N2750/14143 ,  C12Y115/01001

摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of modulatory polynucleotides.

公开(公告)号：EP3331610A1

公开(公告)日：2018-06-13

申请号：EP16739411.3

申请日：2016-07-06

申请人： Ruprecht-Karls-Universität Heidelberg ,  Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts

发明人： OSSWALD, Matthias ,  WICK,Wolfgang ,  WINKLER, Frank ,  JUNG, Erik ,  BLAES, Jonas

IPC分类号： A61P35/00 ,  C12N15/113 ,  A61K31/155 ,  A61K31/495 ,  A61K31/4985 ,  A61K31/522 ,  A61K31/713

CPC分类号： A61K39/39558 ,  A61K31/13 ,  A61K31/155 ,  A61K31/16 ,  A61K31/495 ,  A61K31/497 ,  A61K31/4985 ,  A61K31/515 ,  A61K31/522 ,  A61K31/5377 ,  A61K31/7105 ,  A61K31/713 ,  A61K2300/00 ,  A61P35/00 ,  C12N15/113 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2330/50

摘要： The present invention relates to agents for use in the treatment of glioma, in particular astrocytoma WHO IF and 111°, as well as IV0 (glioblastoma), in a subject.

公开(公告)号：EP3171879A4

公开(公告)日：2018-03-28

申请号：EP15825354

申请日：2015-07-23

申请人： TEL HASHOMER MEDICAL RES INFRASTRUCTURE & SERVICES LTD

发明人： SIDI YECHEZKEL ,  AVNI DROR ,  LERMAN GALI

IPC分类号： A61K31/7105 ,  A61K9/00 ,  A61K31/713 ,  A61K41/00 ,  A61P17/00 ,  A61P17/06 ,  C12N15/113

CPC分类号： C12N15/1136 ,  A61K9/0014 ,  A61K31/7105 ,  A61K31/713 ,  A61K41/0047 ,  A61P17/00 ,  A61P17/06 ,  C12N15/113 ,  C12N2310/141 ,  C12N2310/531 ,  C12N2330/50

摘要： The present invention relates to methods of treating, preventing, reducing the severity of, reducing the incidence of, delaying the onset of, or reducing pathogenesis of an inflammatory skin disease, condition or lesion in a human subject, which include the step of administering to the subject a therapeutically effective amount of mi RNA compositions. In addition, methods of this invention may be used to treat symptoms of inflammatory skin diseases and reduce and/or inhibit keratinocyte proliferation.

公开(公告)号：EP3221461A1

公开(公告)日：2017-09-27

申请号：EP15861129.3

申请日：2015-11-16

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： SMOLKE, Christina D. ,  LI, Yanran

IPC分类号： C12P13/16

CPC分类号： C12P17/188 ,  C07D273/01 ,  C07D515/02 ,  C07D515/14 ,  C07D515/22 ,  C12N1/02 ,  C12N1/14 ,  C12N9/1003 ,  C12N2330/50 ,  C12P13/16

摘要： Engineered non-plant cells that produce a benzylisoquinoline alkaloid product that is a derivative of canadine along a metabolic pathway that converts canadine, or an analog of canadine, to a noscapinoid product are provided. Methods of culturing engineered non-plant cells that produce a noscapinoid product and pharmaceutical compositions are also provided.

摘要翻译： 提供了产生苄基异喹啉生物碱产物的经改造的非植物细胞，所述苄基异喹啉生物碱产物是沿着代替途径将canadine或canadine类似物转化为非类甾体产物的代谢途径的衍生物。 还提供了培养产生非索皮生类产品的工程化非植物细胞和药物组合物的方法。

公开(公告)号：EP3099173A1

公开(公告)日：2016-12-07

申请号：EP15742945.7

申请日：2015-01-26

申请人： Synphagen LLC.

发明人： PARSLEY, Todd, Bernard ,  FREGUIA, Christian, Furlan

IPC分类号： A01N63/00 ,  A61K39/12 ,  C12Q1/70 ,  G01N33/569

CPC分类号： C02F3/34 ,  A01N63/02 ,  A61K38/2066 ,  A61K38/45 ,  A61K38/482 ,  A61K48/005 ,  C12N7/00 ,  C12N15/111 ,  C12N15/113 ,  C12N15/70 ,  C12N15/86 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2320/32 ,  C12N2330/50 ,  C12N2795/00021 ,  C12N2795/00031 ,  C12N2795/00032 ,  C12N2795/00043 ,  C12N2795/14143 ,  C12N2820/55 ,  C12Y201/02001 ,  C12Y203/02013

摘要： Compositions for a phage particle are disclosed. The phage particle is non-replicating and includes at least one heterologous nucleic acid sequence that is capable of being expressed in a target bacteria. The expressed heterologous nucleic acid sequence is non-lethal to the target bacteria.

摘要翻译： 对于噬菌体颗粒组合物是游离缺失盘。 噬菌体颗粒是非复制性和包括至少一个异源核酸序列确实是能够在靶细菌被过表达。 过表达的异源核酸序列是是非致死的靶细菌。

公开(公告)号：EP2970971A4

公开(公告)日：2016-11-02

申请号：EP14770615

申请日：2014-03-13

申请人： SHEKDAR KAMBIZ

发明人： SHEKDAR KAMBIZ

IPC分类号： C12N15/113 ,  C12N15/10

CPC分类号： C12N15/1138 ,  C12N15/102 ,  C12N2310/152 ,  C12N2310/3181 ,  C12N2310/3231 ,  C12N2310/333 ,  C12N2310/336 ,  C12N2310/533 ,  C12N2330/50 ,  C12Q1/6876

摘要： The invention provides compositions and methods of making and using effector oligonucleotides, including effector oligonucleotides with greater than one mismatch as compared to its target sequence. These effector oligonucleotides are useful for improving the efficiency of genomic editing as well as providing therapeutic benefits to individuals in need thereof.

公开(公告)号：EP2791336A2

公开(公告)日：2014-10-22

申请号：EP12809048.7

申请日：2012-12-13

申请人： Henry Ford Health System

发明人： KATAKOWSKI, Mark, E. ,  BULLER, Benjamin, A.L. ,  CHOPP, Michael

IPC分类号： C12N15/113 ,  C12N15/11 ,  A61K48/00 ,  A61K31/713

CPC分类号： A61K35/28 ,  A61K9/127 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/141 ,  C12N2320/32 ,  C12N2330/50

摘要： Some embodiments comprise methods, systems, and compositions to produce and/or administer modified exosomes or other vesicles containing one or more selected microRNAs, including but not limited to, miR-146b. Some embodiments also comprise the therapeutic administration and use of such modified exosomes and/or producer cells to treat mammalian injuries and diseases, including in human beings.

摘要翻译： 一些实施例包括方法，系统和组合物，以产生和/或管理一个含改性外来体或其它囊泡或多个所选择的微小RNA，包括但不限于的miR-146b中。 因此，一些实施例包括治疗性给药和使用搜索改性外来体和/或生产细胞的治疗哺乳动物的损伤和疾病，包括人类。

公开(公告)号：EP2542677A1

公开(公告)日：2013-01-09

申请号：EP11704847.0

申请日：2011-02-16

申请人： University College Cardiff Consultants Limited

发明人： HARDING, Keith ,  JIANG, Wen Guo

IPC分类号： C12N15/113 ,  A61K31/7088 ,  A61K31/403

CPC分类号： A61K38/12 ,  A61K9/0014 ,  A61K31/403 ,  A61K48/00 ,  C12N15/113 ,  C12N2310/121 ,  C12N2310/14 ,  C12N2320/30 ,  C12N2320/31 ,  C12N2330/50

摘要： The invention relates to at least one molecular target for healing or treating wounds and, in particular chronic, human wounds. The molecular target is nWASP or a protein 50% homolgous therewith and which retains the same activity as nWASP protein, such as WASP. Further, the invention concerns a novel therapeutic for treating said wounds and a novel gene therapy approach, involving said molecular target, for treating said wounds.