公开(公告)号：EP2881467A1

公开(公告)日：2015-06-10

申请号：EP13825402.4

申请日：2013-07-30

申请人： National University Corporation Nagoya University ,  Medical & Biological Laboratories Co., Ltd.

发明人： KADOMATSU, Kenji ,  KISHIDA, Satoshi ,  ONO, Kenichiro ,  YAGI, Kasumi

IPC分类号： C12N15/09 ,  A61K39/395 ,  A61P35/00 ,  C07K16/18 ,  C07K16/46 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12P21/08

CPC分类号： C07K16/22 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/90

摘要： A monoclonal antibody, which recognizes at least two amino acids among amino acids located at position 69, position 79, position 81 and position 102 of human midkine, has been found to have excellent reactivity with and excellent neutralizing activity against human midkine. Moreover, the activity of suppressing the proliferation of tumor has been observed in the antibody having excellent neutralizing activity. The use of the antibody of the present invention makes it possible to treat cancer effectively and to detect or purify midkine efficiently.

摘要翻译： 已经发现，在人类midkine的位置69，位置79，位置81和位置102的氨基酸中识别至少两个氨基酸的单克隆抗体具有优异的与人类midkine的反应性和优异的中和活性。 此外，在具有优异的中和活性的抗体中观察到抑制肿瘤增殖的活性。 使用本发明的抗体可以有效地治疗癌症并有效地检测或纯化中期因子。

公开(公告)号：EP2881467B1

公开(公告)日：2018-10-31

申请号：EP13825402.4

申请日：2013-07-30

申请人： National University Corporation Nagoya University ,  Medical & Biological Laboratories Co., Ltd.

发明人： KADOMATSU, Kenji ,  KISHIDA, Satoshi ,  ONO, Kenichiro ,  YAGI, Kasumi

IPC分类号： C12N15/09 ,  A61K39/395 ,  A61P35/00 ,  C07K16/18 ,  C07K16/46 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12P21/08 ,  C07K16/22

CPC分类号： C07K16/22 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/90

摘要： A monoclonal antibody, which recognizes at least two amino acids among amino acids located at position 69, position 79, position 81 and position 102 of human midkine, has been found to have excellent reactivity with and excellent neutralizing activity against human midkine. Moreover, the activity of suppressing the proliferation of tumor has been observed in the antibody having excellent neutralizing activity. The use of the antibody of the present invention makes it possible to treat cancer effectively and to detect or purify midkine efficiently.