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    MOLECULAR MARKER FOR EARLY INDENTIFICATION OF PLEURAL MESOTHELIOMA PATIENTS, AND EXPRESSION ANALYSIS METHOD FOR SAME
    4.
    发明公开
    MOLECULAR MARKER FOR EARLY INDENTIFICATION OF PLEURAL MESOTHELIOMA PATIENTS, AND EXPRESSION ANALYSIS METHOD FOR SAME 审中-公开
    MOLEKULARER MARKER ZURFRÜHENERKENNUNG VON PLEURAMESOTHELIOM-PATIENTEN UND EXPRESSIONSANALYSEVERFAHRENDAFÜR

    公开(公告)号：EP2757376A1

    公开(公告)日：2014-07-23

    申请号：EP12831729.4

    申请日：2012-09-14

    申请人： National University Corporation Nagoya University ,  Medical and Biological Laboratories Co., Ltd. ,  Oncomics Co., Ltd.

    发明人： YANAGISAWA, Kiyoshi ,  TAKAHASHI, Takashi ,  YOKOI, Kohei ,  HASEGAWA, Yoshinori ,  ONO, Ken-ichiro ,  YAGI, Kasumi ,  MASUDA, Hitomi ,  TAKEUCHI, Toshiyuki

    IPC分类号： G01N33/574 ,  C07K14/47 ,  C07K16/18 ,  C12N15/09

    CPC分类号： G01N33/57423 ,  C07K14/47 ,  C07K16/18 ,  G01N33/57407

    摘要： To develop a simple, low-cost and highly reliable testing method for mesothelioma, and a kit used for said testing method.
    The present invention provides a testing method for mesothelioma comprising a step in which the concentration of human periostin protein is measured in at least one type of sample from among samples of the blood or pleural fluid of a subject. The step in which the concentration of human periostin protein is measured may use an antibody directed against human periostin protein. The present invention further provides a kit for diagnosing mesothelioma, said kit including the antibody directed against human periostin protein. In one kit for diagnosing mesothelioma, the diagnosis of mesothelioma determines if a subject that may have mesothelioma has mesothelioma or is healthy. In another kit for diagnosing mesothelioma, the diagnosis of mesothelioma determines if a subject that may have mesothelioma has mesothelioma or has a respiratory illness other than mesothelioma.

    摘要翻译： 开发一种简单，低成本，高可靠性的间皮瘤检测方法，以及用于所述检测方法的试剂盒。 本发明提供了一种间皮瘤的检测方法，其特征在于，在受试者的血液或胸膜液样品中的至少一种样品中测定人骨膜素蛋白的浓度。 测量人骨膜素蛋白浓度的步骤可以使用针对人骨膜素蛋白的抗体。 本发明还提供了用于诊断间皮瘤的试剂盒，所述试剂盒包括针对人骨膜素蛋白的抗体。 在诊断间皮瘤的一个试剂盒中，间皮瘤的诊断决定了可能有间皮瘤的受试者是否具有间皮瘤或健康。 在诊断间皮瘤的另一个试剂盒中，间皮瘤的诊断决定了可能有间皮瘤的受试者是否具有间皮瘤或具有间皮瘤以外的呼吸系统疾病。

    ANTIBODIES TO HUMAN NRG1 PROTEIN
    5.
    发明公开
    ANTIBODIES TO HUMAN NRG1 PROTEIN 审中-公开
    ANTIKÖRPERGEGEN HUMANES NRG1-PROTEIN

    公开(公告)号：EP2955226A1

    公开(公告)日：2015-12-16

    申请号：EP14748891.0

    申请日：2014-02-07

    申请人： Medical & Biological Laboratories Co., Ltd.

    发明人： ONO, Kenichiro ,  YAGI, Kasumi

    IPC分类号： C12N15/09 ,  A61K39/395 ,  A61P35/00 ,  C07K16/18 ,  C12N5/10 ,  C12P21/08

    CPC分类号： C07K16/22 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/73 ,  C07K2317/76 ,  C12N15/09 ,  C12N15/85

    摘要： An object is to provide an antibody capable of specifically recognizing a human NRG1 protein isoform, and suppressing signal transduction in which the isoform is involved. An antibody capable of binding to a region at positions 221 to 234 of a human NRG1-α protein or an antibody capable of binding to a region at positions 213 to 239 of a human NRG1-β1 protein was successfully obtained. Further, it was also found that these antibodies had an activity of suppressing cleavage of the NRG1 protein, an activityofsuppressing phosphorylation of an ErbB3 protein in a cancer cell, and an activity of suppressing in vivo tumor proliferation.

    摘要翻译： 目的是提供能够特异性识别人类NRG1蛋白质同种型的抗体，抑制其中涉及同种型的信号转导。 成功获得能够结合人类NRG1-±蛋白质221〜234位的区域的抗体或能结合人类NRG1-2蛋白质213〜239位的抗体的抗体。 此外，还发现这些抗体具有抑制NRG1蛋白的切割，抑制癌细胞中ErbB3蛋白的磷酸化的活性和抑制体内肿瘤增殖的活性的活性。