公开(公告)号：EP2364695A1

公开(公告)日：2011-09-14

申请号：EP10153194.5

申请日：2010-02-10

申请人： Nitto Denko Corporation

发明人： Hara, Takumi ,  Tamura, Kei ,  Inosaka, Keigo ,  Saeki, Yuji

IPC分类号： A61K9/70 ,  A61K31/4458

CPC分类号： A61K9/7053 ,  A61K31/4458

摘要： Provided is a methylphenidate patch preparation superior in the stability of a drug (methylphenidate and/or a salt thereof) in the patch preparation, skin permeability of a drug during use of the patch preparation, and methylphenidate availability. A patch preparation having a support and an adhesive layer formed on at least one surface of the support, wherein the adhesive layer contains methylphenidate and/or a salt thereof, polyisobutylene and a liquid plasticizer. The liquid plasticizer preferably has an HLB value of 1.0 - 3.3.

摘要翻译： 本发明提供了贴剂制剂中药物（哌甲酯和/或其盐）的稳定性优异的哌甲酯贴片制剂，贴剂制剂使用期间药物的皮肤透过性和哌甲酯可用性。 一种贴片制剂，其具有在所述支持体的至少一个表面上形成的载体和粘合剂层，其中所述粘合剂层含有哌甲酯和/或其盐，聚异丁烯和液体增塑剂。 液体增塑剂优选具有1.0-3.3的HLB值。