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公开(公告)号：EP2206759B1
公开(公告)日：2012-09-05
申请号：EP10250054.3
申请日：2010-01-13
发明人： Ameyama, Satoshi , Inosaka, Keigo
CPC分类号： A61K9/7023 , A61F13/0269 , A61F2013/00902 , C09J7/22 , C09J7/38 , C09J2421/00 , C09J2433/00
摘要： An adhesive preparation comprising an adhesive preparation main body comprising a support and an adhesive layer laminated on at least one surface of the support, and a release liner formed on a surface on the side opposite from the support side of the adhesive layer of the adhesive preparation main body, wherein the adhesive preparation main body has a flat plane area of 1.5 - 15 cm 2 , and a ratio of a flat plane area of the release liner to that of the adhesive preparation main body ([flat plane area (cm 2 ) of release liner]/[flat plane area (cm 2 ) of adhesive preparation main body]) is 1.1 - 7, and the release liner has a separating line. Using the adhesive preparation of the present invention, the adhesive preparation main body can be easily held with fingers and the release liner can secure a holding section having a sufficient area, the release liner can be easily detached from the adhesive preparation main body without touching the adhesive surface with fingers and the adhesive preparation main body can be easily adhered to the skin without touching the adhesive surface with fingers, whereby inconveniences such as mutual adhesion of a certain part of the adhesive surface to other part, curling of the adhesive preparation main body and the like can be prevented.
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公开(公告)号：EP2371359A2
公开(公告)日：2011-10-05
申请号：EP11157779.7
申请日：2011-03-11
IPC分类号： A61K9/70 , A61K31/137
CPC分类号： A61K9/7061 , A61K31/137
摘要： The present invention provides an adhesive preparation, which includes a backing and a pressure-sensitive adhesive layer formed on at least one side of the backing, the pressure-sensitive adhesive layer containing (-)-(R)-N,α,-dimethyl-N-2-propynylphenethylamine and/or a pharmaceutically acceptable salt thereof, a pressure-sensitive adhesive, an antioxidant and a metal hydroxide.
摘要翻译： 本发明提供一种粘合剂制剂，其包括背衬和形成在背衬的至少一侧上的压敏粘合剂层，该压敏粘合剂层含有（ - ） - （R）-N，±， - 二甲基 -N-2-丙炔基苯乙胺和/或其药学上可接受的盐，压敏粘合剂，抗氧化剂和金属氢氧化物。
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公开(公告)号：EP2206759A1
公开(公告)日：2010-07-14
申请号：EP10250054.3
申请日：2010-01-13
发明人： Ameyama, Satoshi , Inosaka, Keigo
CPC分类号： A61K9/7023 , A61F13/0269 , A61F2013/00902 , C09J7/22 , C09J7/38 , C09J2421/00 , C09J2433/00
摘要： An adhesive preparation comprising an adhesive preparation main body comprising a support and an adhesive layer laminated on at least one surface of the support, and a release liner formed on a surface on the side opposite from the support side of the adhesive layer of the adhesive preparation main body, wherein the adhesive preparation main body has a flat plane area of 1.5 - 15 cm 2 , and a ratio of a flat plane area of the release liner to that of the adhesive preparation main body ([flat plane area (cm 2 ) of release liner]/[flat plane area (cm 2 ) of adhesive preparation main body]) is 1.1 - 7, and the release liner has a separating line.
Using the adhesive preparation of the present invention, the adhesive preparation main body can be easily held with fingers and the release liner can secure a holding section having a sufficient area, the release liner can be easily detached from the adhesive preparation main body without touching the adhesive surface with fingers and the adhesive preparation main body can be easily adhered to the skin without touching the adhesive surface with fingers, whereby inconveniences such as mutual adhesion of a certain part of the adhesive surface to other part, curling of the adhesive preparation main body and the like can be prevented.摘要翻译： 一种粘合剂制剂，包括粘合剂制剂主体，其包含支撑体和层压在所述载体的至少一个表面上的粘合剂层，以及形成在所述粘合剂的所述粘合剂层的与所述粘合剂层的支撑侧相反的一侧的表面上的剥离衬垫 主体，其中所述粘合剂制备主体具有1.5-15cm 2的平面面积，并且所述剥离衬垫的平面面积与所述粘合剂制备主体的平面面积的比（[平面面积（cm 2） 的剥离衬垫] / [粘合剂准备主体的平面面积（cm 2）]）为1.1〜7，剥离衬垫具有分离线。 使用本发明的粘合剂制剂，可以容易地用手指握住粘合剂制剂主体，并且释放衬垫可以固定具有足够面积的保持部分，释放衬垫可以容易地从粘合剂制备主体脱离而不接触 具有手指的粘合剂表面和粘合剂准备主体可以容易地粘附到皮肤上而不用手指接触粘合剂表面，由此诸如粘合剂表面的某一部分相互粘附到其它部分的不便，粘合剂准备主体卷曲 可以防止这种情况。
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公开(公告)号：EP2135905A2
公开(公告)日：2009-12-23
申请号：EP09162693.7
申请日：2009-06-15
CPC分类号： C09J139/06 , A61K9/7061 , C08K3/16 , C08K5/09 , C08L2666/02 , C09J7/38 , C09J2205/102 , C09J2433/00
摘要： The present invention provides a patch capable of suppressing adhesive residue on the skin surface upon peeling off from the skin in the presence of water due to perspiration and the like, as well as easy detachment from the skin in the presence of water due to perspiration and the like. The present invention provides a patch comprising a support and an adhesive layer provided on at least one surface of the support, wherein the adhesive layer is formed by crosslinking a blend of the following component (A) to component (D): (A) a copolymer obtained by copolymerization of a monomer containing a carboxyl group, (meth)acrylate and vinylpyrrolidone as essential components; (B) a copolymer obtained by copolymerization of a monomer having a basic group as an essential component; (C) a liquid component, and (D) an acidic compound.
摘要翻译： 本发明提供一种贴片，其能够在由于汗水等引起的水的存在下从皮肤剥离时抑制皮肤表面上的粘合剂残留，并且在汗水的存在下容易与皮肤分离， 类似。 本发明提供了一种贴片，其包括支撑体和设置在支撑体的至少一个表面上的粘合剂层，其中粘合剂层通过将下列组分（A）与组分（D）的共混物交联而形成：（A） 通过使含有羧基的单体（甲基）丙烯酸酯和乙烯基吡咯烷酮作为必要成分共聚得到的共聚物; （B）通过使具有碱性基团的单体作为必要成分的共聚物而得到的共聚物; （C）液体成分，（D）酸性化合物。
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5.发明公开Medical adhesive sheet and production thereof 失效Medizinische Selbstklebefolie und Verfahren zu deren Herstellung
公开(公告)号：EP0891782A2
公开(公告)日：1999-01-20
申请号：EP98113131.1
申请日：1998-07-15
IPC分类号： A61L15/58
CPC分类号： A61L15/58
摘要： A medical adhesive sheet comprising a support and an adhesive layer formed on one side of said support, wherein the adhesive layer comprises an adhesive polymer having a weight average molecular weight of not less than 2,000,000, preferably not less than 2,500,000, and at least one plasticizer compatible with said polymer. The medical adhesive sheet of the present invention simultaneously satisfies the adhesive property to the skin and low irritation property, since it can retain the plasticizer in the adhesive layer, even without a crosslinking treatment. The effects of the present invention can be exerted irrespective of the kind of functional group that the plasticizer and drug have.
摘要翻译： 一种医用胶粘片，其特征在于，在所述支持体的一面形成有支撑体和粘合剂层，其中所述粘合剂层包含重均分子量不小于2,000,000，优选不低于2,500,000的粘合剂聚合物，以及至少一种增塑剂 与所述聚合物相容。 本发明的医用粘合片同时满足与皮肤的粘合性和低刺激性，因为即使不进行交联处理也能够将增塑剂保持在粘合剂层中。 不管增塑剂和药物具有的官能团的种类如何，都可以发挥本发明的效果。
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公开(公告)号：EP2371359A3
公开(公告)日：2012-04-11
申请号：EP11157779.7
申请日：2011-03-11
IPC分类号： A61K9/70 , A61K47/02 , A61K31/137
CPC分类号： A61K9/7061 , A61K31/137
摘要： The present invention provides an adhesive preparation, which includes a backing and a pressure-sensitive adhesive layer formed on at least one side of the backing, the pressure-sensitive adhesive layer containing (-)-(R)-N,α,-dimethyl-N-2-propynylphenethylamine and/or a pharmaceutically acceptable salt thereof, a pressure-sensitive adhesive, an antioxidant and a metal hydroxide.
摘要翻译： 本发明提供一种粘合剂，其包含背衬和在所述背衬的至少一个面上形成的压敏粘合剂层，所述压敏粘合剂层包含（ - ） - （R）-N，α， - 二甲基 -N-2-丙炔基苯乙胺和/或其药学上可接受的盐，压敏粘合剂，抗氧化剂和金属氢氧化物。
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公开(公告)号：EP2110125B1
公开(公告)日：2011-03-02
申请号：EP09158023.3
申请日：2009-04-16
发明人： Tamura, Kei , Inosaka, Keigo , Saeki, Yuji
IPC分类号： A61K9/70 , A61K31/565
CPC分类号： A61K31/565 , A61K9/7053 , A61K9/7092
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公开(公告)号：EP1997520B1
公开(公告)日：2010-11-24
申请号：EP08251906.7
申请日：2008-05-30
IPC分类号： A61L15/58 , A61K9/70 , C09J133/10
CPC分类号： A61K9/7053 , A61K9/7061 , A61L15/585 , C08F220/34 , C08F2220/1858 , C08L33/08 , C08L33/14 , C08L39/06 , C08L2666/04 , C09J133/08 , C09J133/14 , C09J139/06 , C08F226/10 , C08F220/06 , C08F220/14 , C08F2220/1825
摘要： The present invention aims at provision of a patch with suppressed occurrence of adhesive residue on the skin after peeling in the presence of water due to perspiration and the like. The patch has an adhesive layer provided on at least one surface of a support, and the adhesive layer is formed by blending the following component (A) - component (C): (A) a copolymer obtained by copolymerization of a monomer containing a carboxyl group, (meth)acrylic acid ester and vinylpyrrolidone as essential components; (B) a copolymer obtained by copolymerization of a monomer having a basic group and (meth)acrylic acid ester as essential components; and (C) a liquid component, and crosslinking the blend.
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公开(公告)号：EP2052718A1
公开(公告)日：2009-04-29
申请号：EP08253376.1
申请日：2008-10-17
发明人： Inosaka, Keigo , Tamura, Kei , Yoshino, Osamu
CPC分类号： A61K9/7053 , A61K47/10 , A61K47/32
摘要： The present invention aims at provision of a patch preparation having a small area and permitting adhesion for a long time.
The present invention provides a patch preparation having an adhesive layer on at least one surface of a support, wherein the adhesive layer contains an adhesive, a poorly soluble drug, a first organic liquid component, a second organic liquid component, a third organic liquid component and crosslinked polyvinylpyrrolidone, the solubility of the poorly soluble drug in the first organic liquid component is not less than the solubility of the poorly soluble drug in the second organic liquid component, and the solubility of the poorly soluble drug in the second organic liquid component is not less than the solubility of the poorly soluble drug in the third organic liquid component.摘要翻译： 本发明的目的在于提供具有小面积并且允许长时间粘合的贴片制剂。 本发明提供了一种在支撑体的至少一个表面上具有粘合剂层的贴片制剂，其中所述粘合剂层包含粘合剂，难溶性药物，第一有机液体组分，第二有机液体组分，第三有机液体组分 和交联聚乙烯吡咯烷酮时，难溶性药物在第一有机液体成分中的溶解度不低于第二有机液体成分中难溶性药物的溶解度，并且难溶性药物在第二有机液体成分中的溶解度为 不低于难溶性药物在第三有机液体组分中的溶解度。
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10.发明公开Percutaneous absorption-type pharmaceutical preparation using a metal chloride, preferably sodium chloride, for preventing cohesive failure 有权使用金属氯化物，优选氯化钠，用于防止粘合的弱点用于经皮吸收的药物组合物
公开(公告)号：EP1731143A1
公开(公告)日：2006-12-13
申请号：EP06011513.6
申请日：2006-06-02
发明人： Inosaka, Keigo , Muraoka, Takateru , Iwao, Yoshihiro , Takada, Akio , Tsuda, Toshinobu , Sekiya, Junichi
IPC分类号： A61K9/70 , A61K31/135 , A61K47/02
CPC分类号： A61K31/135 , A61K9/7061 , A61K47/02
摘要： A stable percutaneous absorption-type pharmaceutical preparation for percutaneous administration of selegiline or selegiline hydrochloride, which does not suffer a decrease in the cohesive force of the adhesive layer therein even in the presence of sweat components due to perspiration during wear and which is free from cohesive failure and resultant adhesive remaining when stripped off, is provided. A percutaneous absorption-type pharmaceutical preparation which comprises: a support; and an adhesive layer containing a metal chloride, an adhesive and at least one of (-)-(R)-N,α-dimethyl-N-2-propynylphenethylamine and its hydrochloride, wherein the adhesive layer is subjected to a crosslinking treatment.
摘要翻译： 用于司来吉兰或司来吉兰盐酸盐，经皮给药的稳定的经皮吸收型药物制剂，其不会遭受以其中即使在汗液组分存在的粘合剂层的凝聚力下降，由于在穿着期间出汗和所有这些是从内聚自由 失败和所得的粘合剂残留时剥离，被提供。 其包括经皮吸收型药物制剂：载体; 和粘合剂层含有金属氯化物，至少一种粘合剂和以（ - ） - （R）-N，±二甲基-N-2-丙炔基苯乙胺和其盐酸盐，worin粘合剂层进行交联处理。
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