公开(公告)号：EP1831208A1

公开(公告)日：2007-09-12

申请号：EP05820639.2

申请日：2005-12-22

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： PRESS, Neil, John ,  COLLINGWOOD, Stephen, Paul

IPC分类号： C07D413/12 ,  C07D403/12 ,  C07D413/14 ,  A61K31/53 ,  A61K31/42 ,  A61K31/454 ,  A61K31/497 ,  A61P11/08

CPC分类号： C07D413/12 ,  C07D211/14 ,  C07D401/12 ,  C07D413/14

摘要： Compounds of formula (I), in salt or zwitterionic form, wherein J, L, M, R1, R2, R3, R4 and R5 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by the muscarinic M3 receptor. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.

公开(公告)号：EP1575950A1

公开(公告)日：2005-09-21

申请号：EP03789283.3

申请日：2003-12-15

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： DENHOLM, Alastair ,  KELLER, Thomas, Hugo ,  MCCARTHY, Clive ,  PRESS, Neil, John ,  TAYLOR, Roger, John

IPC分类号： C07D471/04 ,  A61K31/4375 ,  A61P29/00

CPC分类号： C07D471/04

摘要： Compounds of Formula (I) in free or salt form, wherein R1, R2 and R3 have the meanings as indicated in the specification, are useful for treating conditions mediated by of phosphodiesterase type 4 or the down-regulation or inhibition of TNF-α release, particularly obstructive or inflammatory airways diseases. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

公开(公告)号：EP1831202B1

公开(公告)日：2012-01-18

申请号：EP05850334.3

申请日：2005-12-22

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： PRESS, Neil, John ,  COLLINGWOOD, Stephen Paul

IPC分类号： C07D403/12 ,  C07D413/12 ,  A61K31/4025 ,  A61P11/00

CPC分类号： C07D413/12 ,  C07D403/12

摘要： Compounds of formula (I) in salt or zwitterionic form, wherein R1, R2, R3, R4 and R5 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by the muscarinic M3 receptor. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.

公开(公告)号：EP1831208B1

公开(公告)日：2011-08-24

申请号：EP05820639.2

申请日：2005-12-22

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： PRESS, Neil, John ,  COLLINGWOOD, Stephen, Paul

IPC分类号： C07D413/12 ,  C07D403/12 ,  C07D413/14 ,  A61K31/53 ,  A61K31/42 ,  A61K31/454 ,  A61K31/497 ,  A61P11/08

CPC分类号： C07D413/12 ,  C07D211/14 ,  C07D401/12 ,  C07D413/14

摘要： Compounds of formula (I), in salt or zwitterionic form, wherein J, L, M, R1, R2, R3, R4 and R5 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by the muscarinic M3 receptor. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.

公开(公告)号：EP1831202A1

公开(公告)日：2007-09-12

申请号：EP05850334.3

申请日：2005-12-22

申请人： Novartis AG ,  NOVARTIS-PHARMA GMBH

发明人： PRESS, Neil, John ,  COLLINGWOOD, Stephen Paul

IPC分类号： C07D403/12 ,  C07D413/12 ,  A61K31/4025 ,  A61P11/00

CPC分类号： C07D413/12 ,  C07D403/12

摘要： Compounds of formula (I) in salt or zwitterionic form, wherein R1, R2, R3, R4 and R5 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by the muscarinic M3 receptor. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.

摘要翻译： 盐或两性离子形式的式（I）化合物，其中R 1，R 2，R 3，R 4和R 5具有说明书中所示的含义，可用于治疗由毒蕈碱M3受体介导的病症。 还描述了含有该化合物的药物组合物以及制备该化合物的方法。

公开(公告)号：EP2037915A2

公开(公告)日：2009-03-25

申请号：EP07726173.3

申请日：2007-06-28

申请人： NOVARTIS AG

发明人： COLLINGWOOD, Stephen, Paul ,  FAIRHURST, Robin, Alec ,  PRESS, Neil, John

IPC分类号： A61K31/428 ,  A61K31/4375 ,  A61K31/45 ,  C07D417/12 ,  C07D471/02 ,  A61P11/00

CPC分类号： C07D471/04 ,  C07D277/68 ,  C07D417/14

摘要： Compounds of formula (I) in free or a pharmaceutically acceptable salt form, wherein X1, L and Q have the meanings as indicated in the specification, are useful for treating obstructive or inflammatory airways diseases. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

公开(公告)号：EP3710053A1

公开(公告)日：2020-09-23

申请号：EP18826126.7

申请日：2018-11-16

申请人： Novartis AG

发明人： SABATOS-PEYTON, Catherine, Anne ,  MATARAZA, Jennifer, Marie ,  MACISAAC, Kenzie ,  KWAK, Eunice ,  FARIS, Jason ,  DRANOFF, Glenn ,  WIESMANN, Marion ,  SHARP, Fiona ,  CRYSTAL, Adam ,  CAMERON, John, Scott ,  STRIETER, Robert, Martin ,  PETRUZZELLI, Lilli ,  KAZANI, Shamsah ,  SANDHAM, David, Andrew ,  PRESS, Neil, John ,  HOFFMASTER, Keith

IPC分类号： A61K39/395 ,  C07K16/28 ,  A61P35/00