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公开(公告)号：EP1487435A1
公开(公告)日：2004-12-22
申请号：EP03744367.8
申请日：2003-03-14
申请人： Novartis AG , Novartis Pharma GmbH
IPC分类号： A61K31/397 , C07D205/04 , C07D403/12 , C07D405/12 , C07D417/12 , C07D413/12 , A61P11/06 , A61P11/08 , A61P29/00
CPC分类号： C07D401/12 , C07D205/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Compounds of formula (I) in free or salt form, wherein Ar, X, Y, R1, R2, R3, R5, m, n, p, and q have the meanings as indicated in the specification, are useful for treating conditions mediated by CCR3. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
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公开(公告)号：EP1480962A1
公开(公告)日：2004-12-01
申请号：EP03709730.0
申请日：2003-02-27
申请人： Novartis AG , Novartis Pharma GmbH
发明人： BRUCE, Ian , FINAN, Peter , LEBLANC, Catherine , MCCARTHY, Clive , WHITEHEAD, Lewis , PRESS, Nicola, Elaine , BLOOMFIELD, Graham, Charles , HAYLER, Judy , KIRMAN, Louise , OZA, Mrinalini, Sachin , SHUKLA, Lena
IPC分类号： C07D277/46 , C07D277/48 , C07D417/12 , C07D417/10 , A61K31/426 , A61K31/427 , A61P11/00 , A61P37/08 , A61P19/02 , A61P35/00 , A61P17/06 , A61P37/06 , A61P3/04 , A61P9/10
CPC分类号： C07D277/40 , C07D277/46 , C07D277/48 , C07D417/04 , C07D417/12
摘要： Compounds of Formula I in free or salt form, wherein R1,R2,R3,R4, and R5, have the meanings as indicated in the specification, are useful for treating diseases mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
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公开(公告)号：EP1791815A2
公开(公告)日：2007-06-06
申请号：EP05701246.0
申请日：2005-01-28
申请人： Novartis AG , Novartis Pharma GmbH
IPC分类号： C07D207/12 , A61K31/4015 , A61P11/06
CPC分类号： C07D207/12 , C07D211/26
摘要： Compounds of formula (I) in free or salt form, wherein T, X, Y, U, R1, R2, m, n and p have the meanings as indicated in the specification, are useful for treating conditions mediated by CCR3. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
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公开(公告)号：EP1778628A1
公开(公告)日：2007-05-02
申请号：EP05770044.5
申请日：2005-08-09
申请人： Novartis AG , NOVARTIS-PHARMA GMBH
IPC分类号： C07C275/28 , C07C275/26 , C07C275/34 , C07D261/06 , A61K31/17 , A61P37/08
CPC分类号： C07C275/30 , C07C275/24 , C07C275/28 , C07C275/34 , C07D261/14
摘要： Compounds of formula (I) in free or salt form, wherein T, X, R1, R2, Ra, R3, R4, R5 and U have the meanings as indicated in the specification, are useful for treating a condition mediated by CCR-3, particularly an inflammatory or allergic condition such as an inflammatory or obstructive airways disease. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
摘要翻译： 游离形式或盐形式的式（I）化合物，其中T，X，R1，R2，Ra，R3，R4，R5和U具有说明书中所示的含义，可用于治疗由CCR-3介导的病症 特别是炎性或过敏性病症，例如炎性或阻塞性气道疾病。 还描述了含有用于制备该化合物的化合物和方法的药物组合物。
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公开(公告)号：EP1575950A1
公开(公告)日：2005-09-21
申请号：EP03789283.3
申请日：2003-12-15
申请人： Novartis AG , Novartis Pharma GmbH
发明人： DENHOLM, Alastair , KELLER, Thomas, Hugo , MCCARTHY, Clive , PRESS, Neil, John , TAYLOR, Roger, John
IPC分类号： C07D471/04 , A61K31/4375 , A61P29/00
CPC分类号： C07D471/04
摘要： Compounds of Formula (I) in free or salt form, wherein R1, R2 and R3 have the meanings as indicated in the specification, are useful for treating conditions mediated by of phosphodiesterase type 4 or the down-regulation or inhibition of TNF-α release, particularly obstructive or inflammatory airways diseases. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
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公开(公告)号：EP2421612A1
公开(公告)日：2012-02-29
申请号：EP09779322.8
申请日：2009-04-21
申请人： Novartis AG
发明人： CHIKKANNA, Dinesh , MCCARTHY, Clive , MOEBITZ, Henrik , PANDIT, Chetan , SISTLA, Ramesh , SUBRAMANYA, Hosahalli
IPC分类号： A61P35/00 , A61K31/4353 , C07D471/04 , C07D471/14
CPC分类号： C07D471/14 , C07D471/04 , C07D491/14
摘要： The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts. These compounds can act as potential MEK inhibitors in the treatment of hyperproliferative diseases, like cancer and inflammation. The present invention also reveals methods of preparation thereof.
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公开(公告)号：EP2094645A1
公开(公告)日：2009-09-02
申请号：EP07847275.0
申请日：2007-11-22
申请人： NOVARTIS AG
发明人： FREDERIKSEN, Mathias , LÜÖND, Rainer Martin , MCCARTHY, Clive , MOEBITZ, Henrik , RONDEAU, Jean-Michel , ROY, Bernard Lucien , RUEEGER, Heinrich
IPC分类号： C07C233/40 , C07D213/74 , C07D231/38 , C07D237/20 , C07D239/42 , C07D239/46 , C07D239/52 , C07D261/14 , C07D401/12 , C07D487/04 , A61K31/505 , A61K31/44 , A61K31/165 , A61P25/28
CPC分类号： C07D401/12 , C07C233/40 , C07C2601/02 , C07D213/74 , C07D231/38 , C07D237/20 , C07D239/42 , C07D239/47 , C07D239/52 , C07D261/14 , C07D487/04
摘要： The invention relates to novel cyclic compounds of the formula (I), in free base form or in acid addition salt form, to their preparation, to their use as medicaments and to medicaments comprising them.
摘要翻译： 本发明涉及式（I）的新型环状化合物，其游离碱形式或酸加成盐形式，用于其制备，用作药物和包含它们的药物。
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公开(公告)号：EP2509964B1
公开(公告)日：2014-04-30
申请号：EP10790407.0
申请日：2010-12-07
申请人： Novartis AG
发明人： BOCK, Mark G. , CHIKKANNA, Dinesh , MCCARTHY, Clive , MOEBITZ, Henrik , PANDIT, Chetan , PODDUTOORI, Ramulu
IPC分类号： C07D263/56 , C07D307/79 , A61K31/423 , A61K31/343 , A61P29/00 , A61P35/00
CPC分类号： C07D263/56 , C07D307/79
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公开(公告)号：EP2509964A1
公开(公告)日：2012-10-17
申请号：EP10790407.0
申请日：2010-12-07
申请人： Novartis AG
发明人： BOCK, Mark G. , CHIKKANNA, Dinesh , MCCARTHY, Clive , MOEBITZ, Henrik , PANDIT, Chetan , PODDUTOORI, Ramulu
IPC分类号： C07D263/56 , C07D307/79 , A61K31/423 , A61K31/343 , A61P29/00 , A61P35/00
CPC分类号： C07D263/56 , C07D307/79
摘要： The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof. The compounds have been demonstrated as inhibitors of MEK and therefore may be useful in the treatment of hyperproliferative diseases (e.g., cancer and inflammation).
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公开(公告)号：EP2817307A1
公开(公告)日：2014-12-31
申请号：EP13717317.5
申请日：2013-02-22
申请人： Novartis AG
发明人： CARAVATTI, Giorgio , FAIRHURST, Robin Alec , FURET, Pascal , STAUFFER, Frédéric , SEILER, Frank Hans , RUEEGER, Heinrich , MCCARTHY, Clive
IPC分类号： C07D413/14 , A61K31/5377 , A61P35/00
CPC分类号： C07D498/04 , A61K31/5377 , A61K45/06 , C07D413/14
摘要： The present invention relates to oxazolidin-2-one subsituted pyrimidine compounds that act as PI3K (phosphatidylinositol-3-kinase) inhibitors, as well as pharmaceutical compositions thereof, methods for their manufacture and uses for the treatment of conditions, diseases and disorders dependent on PI3K.
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