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1.发明公开FERMENTATIVE PREPARATION PROCESS FOR CYTOSTATICS AND CRYSTAL FORMS THEREOF 有权PROCEDURE发酵产生细胞抑制剂及晶体形式的
公开(公告)号：EP1054994A2
公开(公告)日：2000-11-29
申请号：EP99911678.3
申请日：1999-02-17
发明人： HOFMANN, Hans , MAHNKE, Marion , MEMMERT, Klaus , PETERSEN, Frank , SCHUPP, Thomas , KÜSTERS, Ernst , MUTZ, Michael
IPC分类号： C12P17/18 , C07D493/04 , B01D15/08
CPC分类号： C07D493/04 , C07D417/14 , C07K2299/00 , C12P17/167 , C12P17/181 , C12R1/01
摘要： The invention relates to a process for concentrating epothilones in culture media, a process for the production of epothilones, a process for separating epothilones A and B and a strain obtained by mutagenesis for the production of epothilones, as well as aspects related thereto. Crystal forms of epothilone B are also described.
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2.发明授权FERMENTATIVE PREPARATION PROCESS FOR CYTOSTATICS AND CRYSTAL FORMS THEREOF 有权PROCEDURE发酵产生细胞抑制剂及晶体形式的
公开(公告)号：EP1054994B1
公开(公告)日：2004-11-17
申请号：EP99911678.3
申请日：1999-02-17
申请人： Novartis AG , Novartis Pharma GmbH
发明人： HOFMANN, Hans , MAHNKE, Marion , MEMMERT, Klaus , PETERSEN, Frank , SCHUPP, Thomas , KÜSTERS, Ernst , MUTZ, Michael
IPC分类号： C12P17/18 , C07D493/04 , B01D15/08 , A61K31/335 , A61P35/00
CPC分类号： C07D493/04 , C07D417/14 , C07K2299/00 , C12P17/167 , C12P17/181 , C12R1/01
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